Prevalence and genetic analysis ofα-andβ-thalassemia in Baise region,a multi-ethnic region in southern China. HE X M,ZHOU Y Q,LUO G X,et al. Gene . 2017He S, Qin Q, Yi S, et a1. Prevalence and genetic analysis of α-and β-thalassemia in Baise region, a multi-ethnic region ...
Testing for α-thalassemia includes: hematologic testing of red blood cell indices, peripheral blood smear, supravital stain to detect RBC inclusion bodies, and qualitative and quantitative hemoglobin analysis. HBA1, the gene encoding α1-globin, and HBA2, the gene encoding α2-globin, are the ...
Prevalence of -alpha(3.7) and alpha alpha alpha(anti3.7) alleles in sickle cell trait and beta-thalassemia patients in Mexico. The aim of this study was to determine the frequency of alpha-globin gene mutations in three groups of Mexican unrelated individuals. The first two groups ... MP Na...
The invention relates to the technical field of biology and medicament, and particularly relates to a gene detection kit for Hong Kong alpha-thalassemia. According to the invention, the gene sequence of HK alpha alpha fusion gene is further confirmed and compared with alpha-globin sequence for ...
molecular analysisthalassaemia intermediaThere are few studies investigating alpha globin gene triplications in -thalassemia in Asian Indians and its effect on phenotype, which was the primary aim of this study. Gap-PCR was performed in order to detect common alpha thalassemia determinants (±3.7, ±...
α-Thalassemia (α-thal) is a hereditary autosomal recessive anemia caused by deletions or mutations within the α-globin gene cluster consisting of two almost identical alpha 1 (α1) and alpha 2 (α2) globin genes on each copy of chromosome 16. ...
Sequence analysis identified a nonsense mutation in exon 2 of the alpha2-globin gene, at amino acid codon 54 (CAG>TAG).关键词: α-Thalassemia (α-thal Point mutation Nonsense mutation DOI: 10.1080/03630260802625980 被引量: 4
A new mutation in IVS-1 of the human beta globin gene causing beta thalassemia due to abnormal splicing A G to T transversion at the fifth nucleotide of the first intervening sequence (IVS-1) of the beta-globin gene has been identified in cloned beta-thalassemia genes of two unrelated indi...
Test kit for alpha-thalassemia gene mutationsTest kit for alpha-thalassemia gene mutationsThe invention provides a test kit for alpha-thalassemia gene mutations. The test kit comprises a set of primer combinations for amplifying target genes in samples. The test kit is capable of performing embryo ...
Molecular analysis of alpha globin gene deletions among patients with microcytic hypochromic anemia in Kermanshah-Iranalpha thalassemiadeletional mutationsKermanshahGAP PCRmicrocytic hypochromic anemiaBackground: The majority of α-thalassemi mutations are deletions of one or both α-globin genes. Since ...