BPH alpha blockers relax the prostate and bladder neck muscles by blocking alpha1 adrenoreceptors, protein molecules that stimulate muscle contraction when activated by the hormones,epinephrine, and norepinephrine. Some BPH alpha-blockers selectively block alpha1A receptors, a subtype that is predominant...
PIH53 Alpha Blockers, 5Alpha Reductase Inhibitors, PDE5 Inhibitors and Antimuscarinic Medication Use in US Patients Diagnosed with Benign Prostatic Hyperplasia, and Lower Urinary Tract Symptoms with and Without Erectile Dysfunction - ResearchGate
Liao, H.-C. Kuo, Progression of lower urinary tract symptoms after discontinuation of 1 medication from 2-year combined alpha-blocker and 5-alpha--Reductase inhibitor therapy for benign prostatic hyperplasia in men--A randomized multicenter study, Urology 83 (2014) 416-421....
Potential pathophysiological hypotheses include that the introduction of TNF alpha blockers may alter the cytokine balance in patients with a genetic predisposition, having genetic factors like NOD2/CARD15 gene mutations, which may result in background conditions for the development of IBD [3]. ...