: any of a group of drugs (as doxazosin and terazosin) that combine with and block the activity of an alpha-receptor to relax smooth muscle (as of blood vessels) and are used especially to treat hypertension and benign prostatic hyperplasia compare beta-blocker ...
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Alpha-1 adrenoceptor blockerApoptosisDrug development has often occurred serendipitously, rather than by using rational approaches. Drug repositioning is an approach that can exploit serendipitous features of a licensed drug. Drug repositioning has mainly been used to develop anti-tumor drugs. There are ...
beta-adrenoceptor blocking drugs Group of drugs (casually referred to as beta-blockers) which block β-adrenoreceptors. Used in the treatment of angina, hypertension, migraine, thyrotoxicosis and anxiety states. Some are relatively unselective (e.g. propranolol), others act primarily on ...
1 Guideline: Preoperative Medication Management Quick Guide for Preoperative Medication Management Medication Class Examples CONTINUE up to and including the day of surgery: Alpha1 Blockers Doxazosin, prazosin, tamsulosin Alpha2 Agonists Clonidine, guanfacine, methyldopa Antianxiet...
Liposomes and emulsions are well known examples of delivery vehicles or carriers for hydrophobic drugs. In a presently preferred embodiment, long-circulating, i.e., stealth liposomes can be employed. Such liposomes are generally described in Woodle, et al., U.S. Pat. No. 5,013,556. The ...
Use of vasoactive drugs (at or within 3 months of Screening) that may impair hepatic blood flow; examples include but are not limited to: -β-blockers, including carvedilol-Nitrates-Vasopressin (or analogues)-Phosphodiesterase inhibitors (prescribed daily for pulmonary hypertension; p.r.n. use ...
epidemiological data suggests that L-type calcium channels blockers may protect from PD160. Thus, examination of whether the expression levels of various Ca2+channels are altered in different brain areas of aSyn transgenic, knockout, or wild-type mice and whether the aSyn released through such ch...
[149]. A previous study developed a tetrandrine-loaded PVP-b-PCL and assessed the delivery of the drug to A549 cells and the cytotoxicity as a result[150].Tetrandrine, a bis-benzylisoquinoline alkaloid, is acalcium channel blockerand preventsmultidrug resistanceby binding to P-glycoprotein[151]....
Golimumab is a TNF-alpha blocker used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. In addition, human monoclonal antibody ustekinumab (Centocor, Inc, Malvern, Pa.), described in U.S. Pat. Nos. 6,902,734 and 7,166,285, is directed against...