beta, delta, gamma/PP, and epsilon) that secrete different hormones to control glucose homeostasis. Their (dys)function and/or death is central to the genetic etiology1and pathophysiology2of all forms of diabetes. Recent islet single cell3,4,5,6,7,8,9and enriched cell population10,11,12,1...
ATS is an autosomal recessive disorder caused by mutations in the solute carrier family 2 member 10 (SLC2A10) gene that encodes for the glucose transporter GLUT10 (Table 2) [7]. Early in their lives, patients usually present with characteristic dysmorphic features: hyperextensible skin and joint...
thuringiensis LBIT 418 showed to be able to act on starch, and the kinetic study showed, at first, the release of dextrins with five or more glucose residues as main products; later, part of the dextrins were converted to maltotrioses and low amounts of maltose and glucose, which ...
rhamnosus extract (1 g/kg) was able to reduce glucose excursions (Area under curve; 22 %; p < 0.05) in rats during a carbohydrate challenge (starch; 2 g/kg). Conclusion These results definitively demonstrate that Lactobacillus strains present in the human gut have alpha- and beta-...
PPARα in atherosclerosis and inflammation PPARα regulates the expression of genes encoding proteins that are involved in lipid metabolism, fatty acid oxidation, and glucose homeostasis, thereby ... F Zandbergen,J Plutzky - BBA - Molecular and Cell Biology of Lipids 被引量: 448发表: 2007年 Var...
Peritoneal dialysis solutions inhibit the differentiation and maturation of human monocyte-derived dendritic cells: effect of lactate and glucose-degradati... Peritoneal dialysis (PD) is a well-established therapy for end-stage renal failure, but its efficiency is limited by recurrent peritonitis. As ...
The physiolog- ical function of aS has been associated with neurotransmitter release16, synaptic vesicle trafficking17 and SNARE complex assembly18, but the details of its functions are yet to be elucidated. However, aS knock-out mice are viable and present only small alterations in DA level and...
The effects on insulin release of alpha-D-mannose and equilibrated D-mannose were studied in the isolated perfused rat pancreas. Although phosphomannose isomerase, in contrast to phosphoglucose isomerase, is stereospecific for beta-D-mannose-6-phosphate, the alpha anomer of D-mannose (2 mg/ml) ...
glucose falls below this level, whereas the beta cell is activated to secrete insulin when this level is exceeded. Expressed differently, the inhibitory glucose dependency curve foralpha cellsand the stimulatory glucose dependency curve for beta cells have their crossover point at 5mM, which is the...
Under a Creative Commons license open accessHighlights Abstract Objective Although glucagon-secreting α-cells and insulin-secreting β-cells have opposing functions in regulating plasma glucose levels, the two cell types share a common developmental origin and exhibit overlapping transcriptomes and epigenome...