Hintermann E, Yang N, O'Sullivan D, Higgins JM, Quaranta V: Integrin alpha6beta4-erbB2 complex inhibits haptotaxis by up-regulating E- cadherin cell-cell junctions in keratinocytes. J Biol Chem 2005, 280(9):8004-8015.Hintermann, E., Yang, N., O'Sullivan, D., Higgins, J. M. and...
For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signaling. Two transcript variants encoding different isoforms have been found for ...
3B), supporting that integrin β1, β6, and β8 play a minor role in mediating fibroblast migration on osteopontin. Figure 3: Integrins αVβ5 and αVβ3 are main integrin receptors contributing to Src-mediated fibroblast migration and Src activation on osteopontin. (A) Fibroblasts were ...
Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epit...
In rats, it is suggested that one beta subunit out of three subtypes could be connected to this alpha subunit. View chapterExplore book Related terms: Eicosanoid Receptor G Protein C-Terminus Amino Acid GABAA Receptor T Cell Amino Terminal Sequence Beta Chain Sodium Channel Integrin View all ...
integrin complex through heterodimerization with one of five β subunit binding partners: beta 1 (β1), beta 3 (β3), beta 5 (β5), beta 6 (β6), or beta 8 (β8). The first αvintegrin characterized was αvβ3, which was originally termed the “vitronectin receptor,” as it ...
Breast cancers acquire aggressive capabilities via epithelial to mesenchymal transition (EMT), in which various integrins/integrin-linked kinase signalling are upregulated. We investigated this in two patient-derived xenografts (PDXs) developed from brea
All three isoforms (PKBalpha, PKBbeta... KS Walker,M Deak,A Paterson,... - 《Biochemical Journal》 被引量: 529发表: 1998年 P53 Inhibits α6β4 Integrin Survival Signaling by Promoting the Caspase 3–Dependent Cleavage of Akt/PKB Although the interaction of matrix proteins with integrins is...
GPIIb/IIIa has been termed the responsive integrin in recognition of its ability to transmit outside-in as well as inside-out signals during platelet activation (Hato et al., 2002; Hynes, 2002). These functional attributes were recognized well in advance of detailed knowledge of the receptor st...
Description: The RMV-7 monoclonal antibody reacts with the mouse CD51 molecule, the integrin alpha v chain. This approximately 120 kDa surface molecule non-covalently associates with the beta subunits of the integrin family including beta3 (CD61), beta1 (CD29), beta5 and beta6 ...