Alpha-amylase (EC 3.2.1.1) is a low-molecular-weight enzyme (approximately 45kDa) that cleaves the alpha-D-(1–4) glycan linkage of starch and glycogen. It has been in use as a diagnostic enzyme longer than any of the other enzymes. It is found in very high concentration in the pancr...
However, both toxins also block the α3β2 nAChR with nano- molar potency[128]. Structure-function analysis was used to create two analogs of α-CTx ArIB, α-CTx ArIB[V11L; V16A] and α-CTx ArIB[V11L; V16D], which have high affinity for α7 nAChRs but have comparatively low ...
As carboxylesterases are located in the whole body, it is thought that the probability of their saturation and the possibility of interaction with substrates with other drugs are low [1,18]. The majority of carboxylesterases belong to one of the two families: CES1 or CES2. In people, the ...
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The S1 pocket of the enzyme, which is adjacent to the surface and bordered with the side chains of residues 189–195, 213–220 and 226–228, was revealed to be associated with the spe- cificity of serine proteases32. Thus, we focused on the structure changes in the S1 specificity ...
Identification of Sp1-binding sites in the CD11c (p150,95 alpha) and CD11a (LFA-1 alpha) integrin subunit promoters and their involvement in the tissue-spe... The leukocyte integrins LFA-1 (CD11a/CD18) and p150,95 (CD11c/CD18) mediate cell-cell and cell-extracellular matrix interactions ...
Fig. 2 Comparison of DD, AFP, and free β-hCG MoM among the four groups. a DD MoM; b AFP MoM; c free β-hCG MoM. DD D-dimer, AFP alpha-fetoprotein, free β-hCG Free beta subumit of human chorionic gonadotropin, GH gestational hypertension; PE Preeclampsia, SPE severe preeclampsia ...
1a), it was confirmed that SH-SY5Y cells were positively transfected with the SNCA gene (F(2,13) = 150.43, P < 0.0001; Fig. 1b). The intensity of the aSyn band changed from moderate to substantial as seen in the low-aSyn clone (125% of the plasmid clone, P < 0.05) and the ...
Determination of 226 Ra at low levels in environmental, urine, and human bone samples and 223 Ra in bone biopsy using alpha-spectrometry and metrological traceability to 229 Th/ 225 Ra or 226 RaHere we propose a method that separates radium from other alkaline-earth cations using cation ...
FIG. 4 shows an autoradiography of a dried gel: lane 1, SFV-mSQL; lane 2, the high producing SFVC′b7-LacZ; lane 3, the low producing pSFV3-LacZ; lane 4, mock transfection without RNA and lane 5, SFV1-Pr55gag; which contains the coding sequence of the Gag-precursor of Human ...