Liebhaber SA,Cash FE,Ballas SK.Human alpha-globin gene expression: The dominant role of the alpha-2 locus in mRNA and protein synthesis. Journal of Biological Chemistry . 1986LIEBHABER S A,CASH F E,BALLAS S K.
The meaning of ALPHA GLOBIN is the chain of hemoglobin that is designated alpha and that when deficient or defective causes a form of anemia known as alpha-thalassemia. How to use alpha globin in a sentence.
bind to form functional tetramers, whereas when the deletion leaves the zeta globin gene intact (i.e., SEA), a low level of zeta globin gene expression continues in definitiveerythroid cellswhich can combine with gamma chains and produce small amounts ofHbPortland (ζ2γ2). Unlike the Hb ...
A novel 5.3-kb deletion of the alpha-globin gene cluster was observed in a family from Naples, Southern Italy. It removes the 5' end of the alpha 2-globin gene, causing an alpha (+)-thalassemia defect. Because of the presence of the residual 3' end of the alpha 2-globin gene, we ...
Purpose There are two alpha globin genes (HBA1 and HBA2) which produce proteins which contribute to haemoglobin. Patients normally have 4 copies of the HBA gene, two from each parent. Mutations in these genes can cause alpha thalassaemia (of varying severity) or result in no clinical abnormali...
In order to determine whether any heterogeneity exists in the human α-globin chain, i.e. whether the products of the duplicated genes are identical, we have determined the total sequence of 14 α-globin chains: seven of these were abnormal, while six were normal chains from the same ...
Since the Iranian populaion is a mixture of different ethnic groups, frequency and distribution of globin mutations in various regions of the country need to be clarified. The aim of this study was to determine the common alpha globin gene deletions among individuals with hypochromic microcytic ...
Transcriptional termination and pausing in the human #alpha#2 globin gene. 来自 Semantic Scholar 喜欢 0 阅读量: 10 作者:E Harris,M. Maria 摘要: No abstract available 关键词: Genetics Molecular biology Cytology Genetics Biochemistry 年份: 1991 ...
A novel α-globin gene arrangement in man We report the isolation of a cluster of four α-like globin genes from a bacteriophage λ library of human DNA ( Lawn et al., 1978). Analysis of the cloned DNA confirms the linkage arrangement of the two adult α-globin genes (α1 and α.....
The genetic defect that produces sickle hemoglobin is a single nucleotide substitution at codon 6 of the beta-globin gene on chromosome 11; it results in a point mutation in the beta-globin chain of hemoglobin (substitution of valine for glutamic acid at the sixth position). ▪ Double ...