The present invention relates to monoclonal antibodies to (sweet) proteins, in particular, having alpha__alpha__delta rho__a > 81%, preferably greater than 90%. The preparation of monoclonal antibodies according to the present invention is connected to a conventional___beta_lambda__( The ...
alpha 1肾上腺素能受体A抗体 PubMedPubMed 产品介绍background: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -...
Increasingly, AlphaFold-Multimer is also used to discover new protein–protein interactions (PPIs). Here, we present AlphaPulldown, a Python package that streamlines PPI screens and high-throughput modelling of higher-order oligomers using AlphaFold-Multimer. It provides a convenient command-line ...
Recombinant Alpha1-Antitrypsin IgG1 Fc-Fusion Protein Takeda et al (2021) stated that AAT is a major serine protease inhibitor; and AATD is a genetic disorder characterized by early-onset severe emphysema. In well-selected AATD patients, therapy with plasma-derived AAT (pAAT), "augmentation ther...
the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1- antichymotrypsin and kinetically interferes with its serpin inhibitory activity... Kroczynska,B. - 《Journal of Biological Chemistry》 被引量: 67发表: 2004年 The Alanine/Threonine Polymorphism of the Alpha-1-Antichymot...
Nuclear proteins present selectively in mouse primary chondrocytes and rat chondrosarcoma cells bind to the three putative HMG (High-Mobility-Group) domain protein binding sites in this 48-bp sequence and the chondrocyte-specific proteins likely bind the DNA through minor groove. Together, my results...
The nucleotide sequence of the gene encoded a 659-amino acid protein with a calculated molecular mass of 77,883 Da. The amino acid sequence of the T. litoralis enzyme showed high similarity with those of alpha-amylases of Pyrococcus furiosus, a hyperthermophilic archaeon, and Dictyoglomus ...
该团队于 2024 年 9 月 5 日上线了最新论文《De novo design of high-affinity protein binders with AlphaProteo》。论文链接：https://storage.googleapis.com/deepmind-media/DeepMind.com/Blog/alphaproteo-generates-novel-proteins-for-biology-and-health-research/Protein_Design_White_Paper_2024.pdf 从细胞...
该团队于 2024 年 9 月 5 日上线了最新论文《De novo design of high-affinity protein binders with AlphaProteo》。 论文链接:https://storage.googleapis.com/deepmind-media/DeepMind.com/Blog/alphaproteo-generates-novel-proteins-for-biology-and-health-research/Protein_Design_White_Paper_2024.pdf ...
models (even after optimization). Hence, the models should be interpreted in a qualitative manner. Moreover, in some cases ligand interactions involve parts of the protein that are not modeled with high confidence by AlphaFold; while optimization might improve the local environment, we advise ...