Testing for diagnosing alpha-1 antitrypsin deficiency is generally accurate. Although no single type of AAT test is perfectly accurate, the combination of test methods enables AAT deficiency to be effectively identified with high levels of confidence. Do I need follow-up tests? If you have an ini...
Alpha-1 antitrypsin deficiency (AATD)-mediated liver disease is a toxic “gain-of-function” inflammation in the liver associated with intracellular retention of mutant alpha-1 antitrypsin. The clinical presentation of the disease includes fibrosis, cirrhosis and liver failure. However, the pathogenic ...
Currently, the measurement of alpha-1 antitrypsin levels is recommended in all patients with chronic obstructive pulmonary disease (COPD) regardless of age and severity of the disease [2]. However, this test is rarely requested, and no studies have been carried out in Colombia to determine the ...
Alpha-1 antitrypsin deficiency associated liver disease (AATD-LD) is a rare genetic disorder and not well-recognized. Predicting the clinical outcomes of AATD-LD and defining patients more likely to progress to advanced liver disease are crucial for better understanding AATD-LD progression and promoti...
Inflammatory cytokines, such as alpha 1 antitrypsin (α1-AT), are increased in BC and affect physiological and pathological conditions. This study aimed to evaluate the serum levels of α1-AT and perform a computational analysis of SERPINA1 in BC, as well as their association with molecular ...
Human neutrophil elastase (HNE) is involved in SARS-CoV-2 virulence and plays a pivotal role in lung infection of patients infected by COVID-19. In healthy individuals, HNE activity is balanced by α1-antitrypsin (AAT). This is a 52 kDa glycoprotein, mai
1. Introduction Alpha-1 antitrypsin (AAT1) is a water-soluble serum glycoprotein characterized by circulating in peripheral blood and diffusing in tissues [1] that inhibits the activity of proteolytic enzymes, the primary target of which is neutrophil elastase (NE), particularly in the lower ...
Alpha-1 antitrypsin (AAT) is a member of the serine protease inhibitor superfamily and can inhibit other proteases, such as cysteine aspartic proteases [10,11]. AAT has a broad range of inhibitory functions, including anti-inflammatory properties and, as a result, can limit tissue injury resulti...
1. Introduction Alpha1-antitrypsin deficiency (AATD) is an autosomal codominant hereditary disease that mainly affects the lungs, causing emphysema or chronic bronchitis, while liver disease constitutes the second leading specific cause of AATD-related mortality. If liver affection is present, AATD can...