In healthy newborns with an uneventful perinatal history the normal values for alpha1-antitrypsin were 1.97 +/- 0.44 g/l, and for alpha2-macroglobulin 3.11 +/- 0.69 g/l. No changes in these levels were found during the first week of life. The levels of alpha1-antitrypsin and alpha2-...
The study first concluded that induced diarrhea can cause an increase in alpha 1-antitrypsin clearance; if this is not considered in establishing normal values, there may be an overdiagnosis of excess protein leakage in patients with diarrhea. Second, there is a highly significant statistical ...
[Fecal excretion and the clearance of alpha 1-antitrypsin in patients with Crohn's disease] 来自 NCBI 喜欢 0 阅读量: 16 作者:A López,J Hinojosa,A Miralles,J Primo,JD Bermúdez 摘要: In previous work we defined the normal values of faecal (A1ATF) and their plasmatic clearance (CLAT) ...
A drug combination (CA) formed by ceruletide and alpha-1 antitrypsin showing a predicted value of neuroprotection of 92% was evaluated for their synergic neuroprotective effects in a mouse pre-clinical stroke model. The administration of both drugs in combination was safe and effective in reducing...
α1-antitrypsin (α1AT), a highly abundant circulating serine protease inhibitor, as SARS-CoV-2 entry inhibitor. We show that α1AT suppresses viral replication in cell lines and human airway epithelial cultures and that it binds and inactivates the serine protease TMPRSS2, which enzymatically ...
Intervertebral disc degeneration is a complex disease with high prevalence. It suggests that cell death, senescence, and extracellular matrix degradation are involved in the pathogenesis. Alpha-1 antitrypsin (AAT), a serine protease inhibitor, was previo
Alpha1-antitrypsin (α1AT) is an abundant serine-protease inhibitor in circulation. It has an important role in neutralizing the neutrophil elastase activity. Different pathogenic point mutations like Z(E342K)-α1AT have been implicated in the devel
Semantic Scholar alpha-1foundation.org alpha1.org (全网免费下载) 相似文献 参考文献 引证文献Accelerated Spirometric Decline in New York City Firefighters With α;1-Antitrypsin Deficiency Accelerated spirometric decline in new York City firefighters with alpha(1)- antitrypsin deficiency. Chest. 2010;138:...
The AST-to-platelet ratio index [APRI] was calculated as AST (IU/L) × AST (upper limit of normal [IU/L])−1 × Plt (×109/L)−1 35. Measurement of tri-sialylated mono-fucosylated tri-antennary glycan (A3F) bound to alpha-1 antitrypsin (AAT) Serum concentrations of...
The cell surface serine protease Transmembrane Protease 2 (TMPRSS2) is required to cleave the spike protein of SARS-CoV-2 for viral entry into cells. We determined whether negatively-charged heparin enhanced TMPRSS2 inhibition by alpha-1-antitrypsin (AAT