The concentration of alpha-1-antitrypsin in the serum and in cerebrospinal fluid was determined by radial immunodiffusion technique. In the series, both serum and cerebrospinal fluid alpha-1-antitrypsin concentrations are significantly higher than the mean normal values. No statistical differences are ...
AAT, alpha-1 antitrypsin; AATD, alpha-1 antitrypsin deficiency; LSM, liver stiffness measurement; PAS-D, periodic acid-Schiff-diastase; Pi∗M, normal AAT allele; Pi∗S, mutant SERPINA1 allele variant termed ‘S’; Pi∗Z, mutant SERPINA1 allele variant termed ‘Z’; Pi∗MZ, AAT geno...
www.nature.com/scientificreports OPEN Alpha‑1 antitrypsin inhibits Clostridium botulinum C2 toxin, Corynebacterium diphtheriae diphtheria toxin and B. anthracis fusion toxin Stefanie Lietz , Lena‑Marie Sokolowski , Holger Barth * & Katharina Ernst * The bacterium Clostridium ...
The AST-to-platelet ratio index [APRI] was calculated as AST (IU/L) × AST (upper limit of normal [IU/L])−1 × Plt (×109/L)−1 35. Measurement of tri-sialylated mono-fucosylated tri-antennary glycan (A3F) bound to alpha-1 antitrypsin (AAT) Serum concentrations of...
α1-antitrypsin (α1AT), a highly abundant circulating serine protease inhibitor, as SARS-CoV-2 entry inhibitor. We show that α1AT suppresses viral replication in cell lines and human airway epithelial cultures and that it binds and inactivates the serine protease TMPRSS2, which enzymatically ...
The Combination of Ceruletide and Alpha-1 Antitrypsin Presents Synergic Neuroprotective Potential In Silico To discover potential neuroprotective drug combinations to successfully treat ischemic stroke, we initially applied a machine-learning approach to simulate and computationally reproduce the stroke pathophysi...
Intervertebral disc degeneration is a complex disease with high prevalence. It suggests that cell death, senescence, and extracellular matrix degradation are involved in the pathogenesis. Alpha-1 antitrypsin (AAT), a serine protease inhibitor, was previo
Values of α1-PI concentration and anti-neutrophil elastase activity in ELF at least in the upper normal limit at the end of the study. detection Inhalation of of iαnh1-aPleIdwαel1l-PtoIleinratthede.serum of the patients. Strong increase of α1-PI concentration and ...
A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invent
Alpha-1 antitrypsin (a1-AT), a member of the serine protease inhibitors (serpin) family, is synthesized in the liver and secreted into the bloodstream, from where it reaches the lung by passive diffusion. Its role is mainly to inhibit neutrophil elastase and maintain a physiologic protease/...