Fecal calprotectin, alpha-1-antitrypsin (α 1 -AT) and elastase are noninvasive biomarkers used in the screening of intestinal inflammation, protein-losing enteropathy and exocrine pancreatic dysfunction, respectively. These markers have not been yet validated in the context of ...
The MIA1101 immunogen is purified human a1-Antitrypsin.^M^MMIA1101 detects Alpha1-Antitrypsin which has a predicted molecular weight of approximately 46 kDa.^M^MMIA1101 was formerly sold as a Seradyn product. 靶标信息 Alpha-1-AT is synthesized in the liver and it ...
Alpha-1 antitrypsin antiprotease properties. Although the main substrate of alpha-1 antitrypsin is neutrophil elastase, its spectrum of action extends to other extracellular serine proteases, the cellular wall matriptase, and calpain 1, ADAM-17, and intracellular caspases. 3.4.2 Inhibition of ...
Alpha-1 Antitrypsin or α1-antitrypsin (A1AT) is a protease inhibitor belonging to the serpin superfamily. It is generally known as serum trypsin inhibitor. Alpha 1-antitrypsin is also referred to as alpha-1 proteinase inhibitor (A1PI) because it inhibits a wide variety of proteases. It prote...
One hundred twenty-six gastric carcinomas (68 advanced cancers and 58 early cancers) were examined immunohistochemically for alpha 1-antitrypsin (AAT), alpha 1-antichymotrypsin (ACT), and alpha 2-macroglobulin (AMG) within tumor cells. The incidence of these three protease inhibitors was markedly ...
The calculated synthesis rate of α 1 -antitrypsin was about twice as high in the patient as in the controls. Therefore, both a longer half-life and an increased synthesis rate contribute to the high level of α 1 -antitrypsin in the plasma of the analbuminemic patient. 展开 关键词: An...
Alpha-1-antitrypsin deficiency (AATD) is a rare genetic disorder associated with the development of liver and lung disease. AAT is a 52-kD glycoprotein, produced mainly by hepatocytes and secreted into the blood. Agglomeration of the AAT-protein in hepatocytes can result in liver disease. Exposur...
Testing for diagnosing alpha-1 antitrypsin deficiency is generally accurate. Although no single type of AAT test is perfectly accurate, the combination of test methods enables AAT deficiency to be effectively identified with high levels of confidence. ...
Alpha-1-antitrypsin deficiency (AATD) is a rare genetic disorder associated with the development of liver and lung disease. AAT is a 52-kD glycoprotein, produced mainly by hepatocytes and secreted into the blood. Agglomeration of the AAT-protein in hepatocytes can result in liver disease. Exposur...
Alpha-1-antitrypsin (α 1 -AT) is the major protease inhibitor in blood plasma. It plays a protective role by inhibiting several endogenous proteases. It occurs in the form of several variants and is highly pleomorphic. Some variants such as the S and Z variants are associated with a reduce...