High levels of hemin can cause oxidative stress and inflammation if not neutralized immediately by specialized scavenger proteins. Human alpha1-antitrypsin (A1AT), an acute-phase glycoprotein and important inhibitor of neutrophil proteases, is also a hemin-binding protein. A short-term exposure of ...
Those that consented to the study were subjected to a standardized questionnaire and have their Alpha-1-Antitrypsin level and genotype determined by the AlphaKit.Eleven patients, between the ages of 14 - 17 with a mean age of 16, participated in the study. They were all tall and thin and ...
The Alpha 1-Antitrypsin Human ELISA is used to quantify levels of human alpha 1-antitrypsin in serum, plasma, and urine using only a 5 µL sample volume. Highlights Kit uses sample size of only 5 µL High sensitivity (1.1 ng/mL) ...
Transthyretin (TTR) and alpha 1-antitrypsin (alpha 1-AT) are expressed at high levels in the liver and also in at least one other cell type. We report here... RH Costa,DR Grayson,JE Darnell - 《Molecular & Cellular Biology》 被引量: 1036发表: 1989年 Adenovirus-mediated transfer of a...
Alpha-1 antitrypsin antiprotease properties. Although the main substrate of alpha-1 antitrypsin is neutrophil elastase, its spectrum of action extends to other extracellular serine proteases, the cellular wall matriptase, and calpain 1, ADAM-17, and intracellular caspases. 3.4.2 Inhibition of ...
Testing for diagnosing alpha-1 antitrypsin deficiency is generally accurate. Although no single type of AAT test is perfectly accurate, the combination of test methods enables AAT deficiency to be effectively identified with high levels of confidence. ...
Researchers report on the safety of a gene therapy to treat the common autosomal recessive hereditary disorder alpha 1-antitrypsin (AAT) deficiency in a new article inHuman Gene Therapy. Ad In ATT deficiency, neutrophil proteases destroy the lung parenchyma, the portion of the lungs involved in ga...
One hundred twenty-six gastric carcinomas (68 advanced cancers and 58 early cancers) were examined immunohistochemically for alpha 1-antitrypsin (AAT), alpha 1-antichymotrypsin (ACT), and alpha 2-macroglobulin (AMG) within tumor cells. The incidence of these three protease inhibitors was markedly ...
起源,血清铜蓝蛋白和α- 1 -抗胰蛋白酶水平 翻译结果2复制译文编辑译文朗读译文返回顶部 起源、 血清铜蓝蛋白和阿尔法-1-antitrypsin 级别 翻译结果3复制译文编辑译文朗读译文返回顶部 起源、 血清铜蓝蛋白和阿尔法-1-antitrypsin 级别 翻译结果4复制译文编辑译文朗读译文返回顶部 ...
Indeed, decreased α1-antitrypsin levels in BEAS-2B cells suggest that exposure to PS-MPs increases the risk for chronic obstructive pulmonary disease, and high concentrations of PS-MPs can induce these adverse responses. While low PS-MP levels can only disrupt the protective pulmonary barrier, ...