Alpha-1-antitrypsin: physiology, genetics and pathology. Humangenetik. 1971; 11 (3):177–189.Kueppers, F. 1971. Alpha-1-antitrypsin: physiology, genetics and pathology. Humangenetik 11 (3):177-89.Kueppers, F.: Alpha 1 -antitrypsin: Physiology, genetics and pathology. Hum. Genet. 9 , ...
AAT deficiency was determined, using the Grifols AlphaKit test kits processed at the Alpha-1 Antitrypsin Genetics Laboratory at GeneAidyx LLC (Alachua, Florida), by assessing low serum levels, followed by genotyping, phenotyping and sequencing. Written and informed consent was obtained from all ...
Present address: Kuwait Medical Genetics Center, P. O. Box 31121, Sulibikhat, Kuwait Authors and Affiliations Institute of Pulmonology, Moscow Elena Samilchuk About this article Cite this article Samilchuk, E. Genetic polymorphism of alpha-1-antitrypsin correlates with a classification of African gr...
Alpha1-antitrypsin [SEDA-31, 532; SEDA-33, 674] Adverse reactions to alpha1-antitrypsin concentrate as replacement therapy are rare. In an international randomized clinical trial, 29% of the patients had adverse reactions (0.004 drug-related adverse events per infusion) of which more than 90%...
(1989), In vitro amplification of the α1-antitrypsin gene: Application to prenatal diagnosis. Prenat. Diagn., 9: 177–186. doi: 10.1002/pd.1970090306 Author Information Institute for Molecular Genetics and Department of Medicine, Baylor College of Medicine, Houston, Texas, U.S.A. Publication ...
Areas covered: In this comprehensive review of alpha-1-antitrypsin deficiency, we describe the historical perspective, genetics, epidemiology, clinical presentation and symptoms, screening and diagnosis, and treatments of the condition. Expert commentary: The two most important directions for a...
Muscle biopsy of astronauts in the same study showed an increase of α-1-antitrypsin, that points to a strong stress response induced by spaceflight involving muscle tissue and the proinflammatory setting [121]. Effects of space flight (SF) factors on cosmonaut’s organism were studied u...
α1-antitrypsin (α1AT), a highly abundant circulating serine protease inhibitor, as SARS-CoV-2 entry inhibitor. We show that α1AT suppresses viral replication in cell lines and human airway epithelial cultures and that it binds and inactivates the serine protease TMPRSS2, which enzymatically ...
Alpha-1-antitrypsin deficiency (AATD) is a rare genetic disorder associated with the development of liver and lung disease. AAT is a 52-kD glycoprotein, produced mainly by hepatocytes and secreted into the blood. Agglomeration of the AAT-protein in hepatocytes can result in liver disease. Exposur...
Human Genetics June 1980, Volume 54, Issue 3, pp 361-364 Pi Ecincinnati: A new alpha1-antitrypsin allele in three negro families G. Hug, Gail Chuck, T.M. Slemmer, Magne K. Fagerhol Purchase on Springer.com $39.95 / €34.95 / £29.95* Rent the article at a discount Rent...