Alpha-1 antitrypsin is a circulating glycoprotein mainly synthesized by liver. Most patients with alpha-1 antitrypsin deficiency-associated liver disease are homozygous for the Z mutant. The genetic defect of t
AAT, alpha-1 antitrypsin; AATD, alpha-1 antitrypsin deficiency; LSM, liver stiffness measurement; PAS-D, periodic acid-Schiff-diastase; Pi∗M, normal AAT allele; Pi∗S, mutant SERPINA1 allele variant termed ‘S’; Pi∗Z, mutant SERPINA1 allele variant termed ‘Z’; Pi∗MZ, AAT geno...
Alpha-1抗胰蛋白酶缺乏症的英文名字是Alpha-1 antitrypsin deficiency。基因解码表明:Alpha-1抗胰蛋白酶缺乏症是一种遗传性疾病,与基因突变密切相关。Alpha-1抗胰蛋白酶是一种由SERPINA1基因编码的蛋白质,它在肝脏中合成并通过血液循环分布到全身。该蛋白质的主要功能是
Alpha-1 antitrypsin(抗胰蛋白酶)deficiency is a genetic disorder(遗传病)in which a protein called alpha-1antitrypsin is defective or absent, and it causes lung and liver disease. α抗胰蛋白酶缺乏症是一种遗传性疾病,患者体内的一种叫做α抗胰蛋白酶的蛋白质出现了问题或者含量减少了,最终导致肺和肝脏...
Alpha 1 is the common name for a genetic condition called Alpha 1 Antitrypsin Deficiency. If a person has Alpha 1, the body is unable to produce a protein known as Alpha 1 Antitrypsin, or AAT for short. This protein plays an important role in protecting the lungs from damage due to exce...
ARALAST® NP [Alpha1-Proteinase Inhibitor (Human)] is a medication for severe Alpha 1-antitrypsin deficiency with emphysema. See Important Safety Information.
Alpha-1 antitrypsin deficiency associated liver disease (AATD-LD) is a leading genetic cause of liver disease, yet it remains largely underdiagnosed and poorly understood. This encore webinar from a live symposium will feature a multispecialty panel of experts who will...
Alpha-1-antitrypsinProteaseAntiproteaseLiver diseaseChronic obstructive pulmonary disease (COPDTwo disparate disease states—an adult form of emphysema and a childhood form of liver cirrhosis—have been linked to an inherited absence of this antienzyme. In their severe, homozygous forms, both conditions...
The Alpha One International Registry (AIR), a multinational research program focused on alpha1-antitrypsin (AAT) deficiency, was formed in response to a World Health Organization recommendation. Each of the nearly 20 participating countries maintains a n
Get information about alpha1-antitrypsin deficiency: disease overview, symptoms, treatment options, PROLASTIN-C Liquid therapy, support program, and more.