The prevalence of the Pro227-->Ala mutation was 0.9% and it was not associated with impaired lung function. None of the subjects had the Leu55-->Pro mutation. 展开 关键词: Humans Lung Diseases, Obstructive Proline alpha 1-Antichymotrypsin Genotype Mutation Alanine ...
Gilfix BM, Briones L (1997) absence of the Al252G mutation in alpha 1-antichymotrypsin in a North American population suffering from dementia. J Cereb Blood Flow Metab 17: 233–235
A complex between prostate-specific antigen and alpha 1-antichymotrypsin is the major form of prostate-specific antigen in serum of patients with prostatic... We have studied the forms of prostate-specific antigen (PSA) in serum of patients with prostatic cancer and benign prostatic hyperplasia. Fr...
Role of alpha-1-antichymotrypsin deficiency in promoting cirrhosis in two siblings with heterozygous alpha-1-antitrypsin deficiency phenotype SZ Alpha-1-antitrypsin (A1AT) deficiency is the most common inherited metabolic disorder with the potential to cause injury in the lung and liver. Recent repo....
alpha 1-Antichymotrypsin (ACT), a component of the senile plaque of the Alzheimer's disease (AD) brain, has a possible role as a molecular chaperone in developing AD pathology. This study was a search for the possible association of the two structural polymorphisms of ACT, Ala15-->Thr and...
Gooptu B, Hazes B, Chang WS, Dafforn TR, Carrell RW, Read RJ, and Lomas DA (2000) Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease. Proc Natl Acad Sci USA 97:67-...
Yoon D, Kueppers F, Genta RM, Klintmalm GB, Khaoustov VI, Yoffe B: Role of alpha-1-antichymotrypsin deficiency in promoting cirrhosis in two siblings with heterozygous alpha-1-antitrypsin deficiency pheno- type SZ. Gut 2002, 50:730 -732...
A locus for familial early-onset Alzheimer’s disease on the long arm of chromosome 14, proximal to the α1-antichymotrypsin gene. Nat Genet 1992;2:340–342.Mullan M, Houlden H, Windelspecht M, Fidani L, Lombardi C, Diaz P, Rossor M, Crook R, Hardy J, Duff K, Crawford F. A ...
In this study, we have identified HNF-4[Alpha] target genes that are mainly expressed in the liver, including [Alpha]1-antitrypsin, [Alpha]1-antichymotrypsin, [Alpha]-fetal protein, ceruloplasmin, IGF binding protein 1, transferrin, apolipoprotein(AI) [apo(AI)], ...
Identification of lysines within alpha 1-antichymotrypsin important for DNA binding. An unusual combination of DNA-binding elements. J Biol Chem 270, 14548-14555 (1995).Naidoo N, Cooperman BS, Wang ZM, Liu XZ, Rubin H. Identification of lysines within alpha 1-antichymotrypsin important for ...