Improved genome editing with Cas12a and Cas9 chRDNA platform in T, NK, B, andiPS cells Transplantation & Cellular Therapy Meetings of ASTCT™ and CIBMTR®.February 21-24,2024. High-specificity CRISPR-mediated genome engineering inanti-BCMAallogeneicCAR T cellssuppresses allograft rejection in ...
Allogeneic CAR T cells for autoimmune diseases: a glimpse into the futuredoi:10.1038/s41392-024-01998-8Dimitrios Mougiakakoshttps://ror.org/00ggpsq73grid.5807.a0000 0001 1018 4307Department of Hematology, Oncology, and Cell TherapyOtto-von-Guericke University Magdeburg Magdeburg Germany...
Eidell, K.P., Hemann, M.T.FAS-less allogeneic CAR T cells.Nat. Biomed. Eng8, 1518–1520 (2024). https://doi.org/10.1038/s41551-024-01319-y Download citation Published20 December 2024 Issue DateDecember 2024 DOIhttps://doi.org/10.1038/s41551-024-01319-y ...
If that doesn't work, please contact support so we can address the problem. In immunocompetent hosts, the ablation of FAS and CD3 in allogeneic chimeric antigen receptor T cells confers them with partial protection from rejection by T cells and natural killer cells. This is a preview of subs...
The allogeneic BCMA-targeted CAR T-cell therapy P-BCMA-ALLO1 led to high response rates in heavily pretreated patients with relapsed/refractory multiple myeloma. Patients given the regimen were also able to skip invasive apheresis, bridging therapy, and manufacturing delays, per data from...
A small but in-depth study of allogeneic CAR T cell therapy in patients with high-risk neuroblastoma shows feasibility and potential efficacy, and mechanistic insights reveal pathways to improved functionality of CAR T cells in solid tumors. This is a preview of subscription content, log in via ...
DISCOVER ATARA Atara is an allogeneic T-cell immunotherapy company. We're harnessing the natural biology of T cells—our body’s most effective weapon in fighting disease—to develop transformative therapies for patients with cancer and autoimmune conditions. ...
Difference is Autologous CAR T-cell therapy uses a patient's immune cells while Allogeneic CAR T-cell therapy uses donor T cells or umbilical cord...
While recent clinical data has demonstrated the persistence of therapeutic T cells that had been edited with CRISPR, the extent of gene editing that therapeutic T cells can tolerate has not been fully described. Herein, we have generated CAR-T cells with 10 gene edits. Loss of function alleles...
biomolecules Review Recent Advances in Allogeneic CAR-T Cells Dong Wook Kim and Je-Yoel Cho * Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 151-742,...