烯丙氧基羰基保护基AllocProtectingGroup 概要 烯丙氧基羰基保护基(allyloxycarbonyl, Alloc)、经常用于通过形成氨基甲酸酯形成来保护胺基。 该保护基在强碱性条件下的酯的水解条件・亲核条件・比较弱的质子还原条件下都能显示出比较强的稳定性,通常使用Pd(0)催化的亲核取代反应进行脱保护。 反应机理 保护 烯丙基...
Fernandez-Forner D, Gasals G, Navarro E, Ryder H, Albericio F (2001) Solid-phase synthesis of 4-aminopiperidine analogues using the Alloc protecting group: an investigation of Alloc removal from secondary amines. Tetrahedron Lett 42:4471-4474...
烯丙氧基羰基保护基(allyloxycarbonyl, Alloc)、经常用于通过形成氨基甲酸酯形成来保护胺基。 该保护基在强碱性条件下的酯的水解条件・亲核条件・比较弱的质子还原条件下都能显示出比较强的稳定性,通常使用Pd(0)催化的亲核取代反应进行脱保护。 反应机理 保护 烯丙基氯甲酸酯(Alloc-Cl)常用作反应试剂。加入吡啶或...
烯丙氧基羰基保护基 Alloc Protecting Group 概要 烯丙氧基羰基保护基(allyloxycarbonyl, Alloc)、经常用于通过形成氨基甲酸酯形成来保护胺基。 该保护基在强碱性条件下的酯的水解条件・亲核条件・比较弱的质子还原条件下都能显示出比较强的稳定性,通常使用Pd(0)催化的亲核取代反应进行脱保护。 基本文献 Kunz, H....
N上脱ALLOC NDMBA.pdf,View Online P Enantioselective total synthesis of vicenistatin, a novel E 20-membered macrocyclic lactam antitumor antibiotic R K I a a a a b N Yoshitaka Matsushima, Hiroaki Itoh, Takuya Nakayama, Sayo Horiuchi, Tadashi Eguchi and Ka
Alloc Protecting Group 概要 烯丙氧基羰基保护基(allyloxycarbonyl, Alloc)、经常用于通过形成氨基甲酸酯形成来保护胺基。 该保护基在强碱性条件下的酯的水解条件・亲核条件・比较弱的质子还原条件下都能显示出比较强的稳定性,通常使用Pd(0)催化的亲核取代反应进行脱保护。
Removal of amino- and carboxy-protecting groups and sub- sequent macrolactamization were performed as follows. Initial palladium-catalyzed deprotection of the Alloc group of 27 was somewhat troublesome, i.e. the deprotected free amine hap- pened to react with dimedone, which was the generally us...
faropenem sodium can be obtained by removal of the tbdms protecting group of (VIII) by means of either Et3N tris(hydrogen fluoride) in ethyl acetate or tetrabutylammonium fluoride (TBAF) and HOAc in THF to give compound (IX). This is followed by allyl ester group removal of (IX), which...
Barber P I,Manoharan M.Solid Phase conjugation Chemistry: Use of Alloc as a Protecting Group for 2′Amino-Linker Containing Oligonucleotide. Solid Phase conjugation Chemistry . 1997Barber P I,Manoharan M. Solid Phase conjugation Chemistry:Use of Alloc as a Protecting Group for 2′-Amino-Linker ...
Fernandez-Forner D, Gasals G, Navarro E, Ryder H, Albericio F (2001) Solid-phase synthesis of 4-aminopiperidine analogues using the Alloc protecting group: an investigation of Alloc removal from secondary amines. Tetrahedron Lett 42:4471-4474...