Importantly, the allergic dysregulation was linked to decreased expression of Tgfb1 in gut Treg cells, whose upregulation by the commensal microbiota was essential for their differentiation into oral tolerance-promoting ROR-γt+ Treg cells. In contrast, homozygous Tgfb1 deficiency in Treg cells ...
This study was a retrospective analysis of a prospective birth cohort, utilizing both cross-sectional and longitudinal factorial design as outlined in Fig.1. Characteristics for the subjects selected for this study are shown in Supplementary Table1. The allergic group consisted of slightly more males ...