Alleles come in a variety of forms. The most prevalent or typical allele in nature that encodes the typical or standard form of a trait is known as a wild-type allele. Alleles that have suffered a change or mutation in their DNA sequence and produced a different version of the trait are ...
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Here, we show that DPP8/9 inhibitors are universal activators of all functional mouse NLRP1 alleles (i.e., those that have CARDs and undergo autoproteolysis). Notably, DPP8/9 inhibition activates the mouse NLRP1A protein, and is now the first known agent that activates the NLRP1A inflamma...
Environmental and genetic factors contribute to IR. The main environmental factors are obesity, sedentary behaviour, stress, nutritional factors (such as excessive intake of fructose in liquid form and branched-chain amino acids) and sleep deprivation.4IR is associated with certain well-known human mo...
NLR Frequency for Different Subclasses, Related to Figure 1 NLRs are grouped by domain content: T (TIR), N (NB), C (CC), R (CCR), and X (all IDs). Domains in parentheses are not present in all members of that group. Domain order is not considered. Mean is shown as a solid ...
Forward genetic screens are a powerful approach for identifying the genes contributing to a trait of interest. However, mutants arising in genes already known can obscure the identification of new genes contributing to the trait. Here, we describe a strategy called Candidate gene-Sequencing (Can-Seq...
The two most common types of pancreatic neuroendocrine tumors (PanNETs) are insulinomas and nonfunctioning PanNETs (NF-PanNETs). Insulinomas are small, rarely metastatic tumors that secrete high amounts of insulin, and nonfunctioning PanNETs are larger t
Adjacent chromosomes are colored in different shades of blue. Plotted are variants with P < 0.001. Full size image In addition, we conducted an approximate stepwise conditional analysis for the 123 risk loci (Methods). Since sample sizes per variant varied considerably, we restricted the ...
Parallel serpentine adaptation First, we inferred independent colonisation of each serpentine site by different local A. arenosa populations. To do this, we resequenced five pairs of geographically proximate serpentine (S) and non-serpentine (N) populations covering all known serpentine sites occupied ...
Epimutations are heritable changes in gene function due to loss or gain of DNA cytosine methylation or chromatin modifications without changes in the DNA sequence. Only a few natural epimutations displaying discernible phenotypes are documented in plants