It references the study "MYD88 L265P in Waldenström's Macroglobulinemia, IgM Monoclonal Gammopathy and Other B-Cell Lymphoproliferative Disorders Using Conventional and Quantitative Allele-Specific PCR" by L. Xu and colleagues in a 2013 issue of "Blood." It is said that the MYD88 gene plays...
The present study aimed to develop a real-time allele-specific oligonucleotide PCR (ASO-RQ-PCR) to detect the MYD88 L265P mutation. We first evaluated the reproducibility and sensitivity of the technique with a diluting experiment of a previously known positive sample. Then, we evaluated the ...
MYD88 L265P was absent in 90% of immunoglobulin M (IgM) monoclonal gammopathy of undetermined significance (MGUS) patients. We therefore developed conventional and real-time allele-specific polymerase chain reaction (AS-PCR) assays for more sensitive detection and quantification of MYD88 L265P. ...