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74,75. Although this strategy allows control over dosing at different donor:effector ratios, it also requires higher overall vector doses, which might be toxic to the patient
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Thus, coordinated and omnitemporal functions of all five STIM/Orai and IP3Rs translate the strength of agonist stimulation to precise levels of Ca2+ signaling and NFAT induction, ensuring the fidelity of complex mammalian Ca2+ signaling. Graphical abstract Download: Download high-res image (209KB)...
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