In C. elegans meiocytes progress through meiosis as they move away from the distal tip of the gonad. Germline stem cells are located at the distal gonad tip, surrounded by the distal tip cell (DTC). The DTC is adjacent to a region known as the progenitor zone, which contains a mixed ...
Topoisomerase activity is indispensible to cells, but requires the transient breakage of DNA strands. This property has been exploited, often for significant clinical benefit, by various exogenous agents that interfere with cell proliferation. Despite decades of study, surprising findings involving ...
Functional inhibition of AURKB and the SAC in normal hematopoietic stem/progenitor cells (HSPCs) reproduced hyperdiploid karyotypes with abnormal chromosome structure. We conclude that defects in the condensin complex, AURKB, and SAC are associated with HyperD-ALL, likely representing a pathogenic ...
Gynogenesis is one of unisexual reproduction modes in vertebrates, and produces all-female individuals with identical genetic background. In sexual reproduction vertebrates, the roles of primordial germ cells on sexual dimorphism and gonadal differentiat
The cells were harvested and hypotonically treated with 0.075 M KCl and then fixed in methanol-acetic acid (3:1, v/v) overnight with three changes. Chromosomes were pre- pared via dropping and air drying, then stained in 4 % Giemsa solution for 30 min, and finally examined microscopically...
RTN4R also has been implicated as a susceptibility gene in psychosis through disruption of the brain microstructure [287, 288]. Several recent in vitro studies detect Rtn4r in immune cells, suggesting regulatory functions in immune cell adhesion and migration [289,290,291]. The lack of clear ...
Serious toxic manifestations associated with colchicine include myelosuppression, disseminated intravascular coagulation and injury to cells in the renal, hepatic, circulatory and central nervous systems. These most often occur with excessive accumulation or overdosage[see Overdosage (10)]. ...
cells, biochemistry, photosynthesis and respiration, mitosis and meiosis, DNA and RNA, genetics, ecology, evolution and creation, taxonomy, viruses and bacteria, protists and fungi, and finally animals. Students will learn through texts, videos, online interactives and through hands-on and virtual ...
If universal replicative aging were the case for all microbes, all lineages of unicellular organisms would go extinct when the replicative limit of their constitutive cells was reached. A microbial lineage would only escape extinction if some of its cells could somehow rejuvenate; i.e., if some ...
Through a high-throughput chemical screen, Barrow and co-workers identified I-BET 525762A, a bromodomain inhibitor, as a top hit that augments COX5a protein levels in CI-mutant cybrid cells. In parallel, bromodomain-containing protein 4 (BRD4), a target of I-BET 525762A, was identified usin...