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CADUET may be substituted for its individually titrated components. Patients may be given the equivalent dose of CADUET or a dose of CADUET with increased amounts of amlodipine, atorvastatin, or both for additional antianginal effects, blood pressure lowering, or lipid-lowering effect. CADUET may ...
12.2 Pharmacokinetics The systemic levels of albuterol are low after inhalation of recommended doses. In a crossover study conducted in healthy male and female volunteers, high cumulative doses of albuterol sulfate inhalation aerosol (1,080 mcg of albuterol base administered over one hour) yielded ...
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this phenomenon is reportedly related to enhanced tumour metastasis through the activation of cathepsin, which possess collagenolytic and elastinolytic activities15,16. Legumain can also activate pro-MMP-2, thereby contributing to the degradation of ECM components, such as elastin, fibronectin, lamin,...
which binds to residues K310 on EDIII.10The absence of escape mutants for SIgN-3C thus suggests that the fusion-loop and potentially other conserved residues that are essential for the integrity of the virus structure are critical components of the neutralizing epitope. Further work to identify th...
In contrast, meat and meat products, except for the liver, contain negligible amounts of folate.[2] The most oxidized and stable form is folic acid, a synthetic form of folate, which is composed of three covalently linked components: a pteridine ring, p-aminobenzoic acid, and a glutamate ...
• Pregnancy. Finasteride use is contraindicated in women when they are or may potentially be pregnant. Because of the ability of Type II 5α-reductase inhibitors to inhibit the conversion of testosterone to 5α-dihydrotestosterone (DHT), finasteride may cause abnormalities of the external genitalia...
Plasma levels of albuterol sulfate and HFA-134a after inhaled therapeutic doses are very low in humans, but it is not known whether the components of Albuterol Sulfate HFA Inhalation Aerosol are excreted in human milk. Caution should be exercised when Albuterol Sulfate HFA Inhalation Aerosol is ad...
FIG. 1 is a diagram showing the comparative dissolution profiles of a lag time delayed-release formulation of losartan/simvastatin, prepared in Example 1, and the losartan and simvastatin components of single drugs, Cozaar® and Zocor®, as control groups. FIG. 2 is a diagram showing the ...