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在细胞遗传学和分子水平上,早期T细胞前体ALL(ETP-ALL)与急性髓细胞白血病(AML)或混合型ALL-AML相类似,与预后不良有关,可能受益于AML治疗(低甲基化药物和维奈克拉),并在CR时受益于allo-SCT。迄今为止,缺乏有效的抗T细胞靶向疗法,免疫...
(2002) Additional evidence of genetic changes in children with ALL and TEL/AML1 fusion gene. Leukemia, 16, 1873-1875.Jarosova M, Holzerova M, Mihal V, Blatny J, Lakoma I, Trka J, Pikalova Z, Hrusak O, Indrak K: Additional evidence of genetic changes in children with ALL and ...
Prof Kantarjian is Samsung Distinguished Leukemia Chair in Cancer Medicine and Chair of the Dept of Leukemia at The University of Texas MD Anderson Cancer Center. His research were the basis for the FDA approvals of o...
CALLA reacts with leukemic cells of 110 of 134 patients (82%) with non-T-cell ALL; 1 of 71 (1%) patients with acute myelogenous leukemia (AML); 2 of 7 patients (29%) with chronic myelogenous leukemia in blast crisis; 7 of 92 patients (8%) with other hematologic malignancies; and ...
CALLA reacts with leukemic cells of 110 of 134 patients (82%) with non-T-cell ALL; 1 of 71 (1%) patients with acute myelogenous leukemia (AML); 2 of 7 patients (29%) with chronic myelogenous leukemia in blast crisis; 7 of 92 patients (8%) with other hematologic malignancies; and ...
Causes of death—other than progressive leukemia—in childhood acute lymphoblastic (ALL) and myeloid leukemia (AML): the Dutch Childhood Oncology Group experience. Leukemia 2005; 19: 537–544. Article CAS Google Scholar Möricke A, Reiter A, Zimmermann M, Gadner H, Stanulla M, Löning L...
Between 1981 and 2000, 6609 children (<18 years of age) were treated in five consecutive trials of the Berlin–Frankfurt–Münster (BFM) study group for childhood acute lymphoblastic leukemia (ALL). Patients were treated in up to 82 centers in Germany
treating patients with leukemia have steadily been gaining more effective treatment options, including new therapeutic approaches for patients who historically have had poor prognoses, including those with acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), and acute myeloid leukemia (AML)....
急性T淋巴细胞白血病(T-ALL)是一种早期淋巴样肿瘤,主要是表达未成熟T细胞表面标志物的恶性淋巴母细胞T淋巴母细胞不受控制地增殖并弥漫性浸润骨髓,抑制正常的造血。