Small molecules are usually compared by their chemical structure, but there is no unified analytic framework for representing and comparing their biological activity. We present the Chemical Checker (CC), which provides processed, harmonized and integrat
However, through the design of a highly ordered brick-and-mortar structure with surface chemical modification and toughening mechanisms at multiscale levels, the all-natural bioinspired structural material reconciles its strength and toughness. As shown in Fig. 2c, d, the fracture toughness, KIc, ...
[1] O. Ostroverkhova, “Organic optoelectronic materials: mechanisms and applications,” Chem. Rev., vol. 116, p. 13279, 2016. https://doi.org/10.1021/acs.chemrev.6b00127.Search in Google Scholar PubMed [2] T. Schembri, J. H. Kim, A. Liess, V. Stepanenko, M. Stolte, and ...
We used it to edit essential clock genes鈥攚hose null phenotypes were well characterized鈥攂y transfecting it into a human cell line, U2OS, expressing a rapidly degraded luciferase (dLuc) under a Bmal1 promoter27. This cell line is widely used as a model system to study clock mechanisms, ...
38 Epidemiological studies have found elevated THBS2 level to predict incident mobility disability and all-cause mortality.39,40 SOD2 plays a role in one of the primary defence mechanisms for the buffering of reactive oxygen species and is involved in the oxidative stress pathway.41 SODs catalyse...
Coffee Consumption and Cardiovascular Disease: a condensed review of Epidemiological evidence and mechanisms. J Agric Food Chem. 2018;66(21):5257–63. Article PubMed Google Scholar Chieng D, Canovas R, Segan L, Sugumar H, Voskoboinik A, Prabhu S, et al. The impact of coffee subtypes on...
This study aims to expand the evidence base for using differentiating NSCs for (developmental) neurotoxicity testing, including effects mediated via thyroid hormone and retinoid signaling as mechanisms of endocrine disruption. For this purpose, we employed a detailed time-resolved characterization of the ...
Folate is a crucial nutrient that supports physiological functions. Low folate levels is a risk factor for several diseases, including cardiovascular diseases and neural tube defects. The most used folate supplement is folic acid, a synthetic oxidative f
Fig. 5: MD simulations reveal the deformation and failure mechanisms at the molecular scale. a–c, Atomic structures of CNF only (a), MMT only (b) and MMT/CNF (c) models before and after tensile failure. Insets are the SEM images of the fracture surfaces of CNF only, MMT only and ...
Sexual reproduction is ubiquitous in eukaryotes, but the mechanisms by which sex is determined are diverse and undergo rapid turnovers in short evolutionary timescales. Usually, an embryo’s sex is fated at the moment of fertilisation, but in rare instances it is the maternal genotype that determin...