four indolealkylamines from Chansu showed a high theoretical affinity to a known irritation target,5-HT_(2A)R.These results suggest that Chansu-induced inflammatory irritation is related to the distinct dysregulation of inflammatory lipids,and peripheral 5-HT_(2A)R is a potential target for ...
Target fishing3-aryl-4-alkylpyrazol-5-aminesdesignsynthesisantitumorP53Background: Pyrazol-5-amine derivatives are an important class of heterocyclic compounds. However, there are less 4-alkyl substituted pyrazoles reported.Ma, ShuchaoOuyang, BenWang, LinanYao, Lei...
Finally, aminoacetonitriles were synthesized from alkylamines and aldehydes in the presence of cyanide ions. Such a synthetic strategy allowed the modification of almost all possible substituents of the 2-oxoimidazolidin-4-ylidene-sulfonamides scaffold. Taking advantage of a certain structural similarity...
adamantane phenylalkylamines; 1D and 2D NMR spectroscopy; computational analysis; enzymatic stability; controlled release studies1. Introduction The advent of the current global pandemic, COVID-19, has not only highlighted the need for new active pharmaceutical ingredients (APIs), but it has also ...
Recently, several elegant procedures have focused on the use of transition-metal catalysis [23,24,25,26,27,28,29,30,31] and tandem reactions from o-alkynylbenzamides/aldehydes or o-haloaryl acetylenic ketones/amines (Scheme 1a) [32,33,34,35,36]. However, these successful routes require ...