Disease activitySerum alkaline phosphatase (ALP) and its isoenzymes – liver (L-ALP), fast liver (F-ALP; also called high-molecular-weight ALP), bone (B-ALP) and intestinal (L-ALP) – were measured by agarose electrophoresis after pretreat-ment of sera with neuraminidase in 100 patients ...
Primary biliary cholangitis is a chronic and progressive autoimmune liver disease, whose prognosis can be improved by normalizing alkaline phosphatase and bilirubin. While ursodeoxycholic acid (UDCA) is first line standard of care, approximately 40 % of patients exhibit incomplete response. We aimed to...
When should I worry about alkaline phosphatase? Your doctor will let you know what high or low alkaline phosphatase levels mean. But you should seek medical help if you have symptoms like yellowing skin or pain in your bones or joints. Those could be a sign of liver or bone disease. What...
Alkaline Phosphatase and Liver Disease Theserum alkaline phosphataseactivity rises in many liver diseases, the highest levels occurring with obstruction to the flow of bile, either intrahepatic or extrahepatic, or with intrahepatic space-occupying lesions such as primary or metastatic liver tumours. The ...
It can be concluded that, in addition to tissue-unspecific alkaline phosphatase, intestinal and placental isozymes contribute to the total alkaline phosphatase activity for patients with liver disease. The results suggest that specific methods for the identification of alkaline phosphatase isozymes could ...
Serum alkaline phosphatase isoenzymes: An aid to the diagnosis of liver diseases Aims: To conduct a review of the literature concerning existing methods to detect alkaline phosphatase (ALP) in human serum and to examine the dietary fact... Toshitugu,Oda,Hiroshi,... - 《Journal of Gastroenterolo...
The activity of alkaline phosphatase was remarkably higher than that of neutral one.───土壤碱性磷酸酶活性显著地高于中性磷酸酶活性. Objective To discuss the relationship of alkaline phosphatase (ALP) isoenzyme and metastasis of carcinoma.───目的探讨碱性磷酸酶(ALP)同工酶与肿瘤转移的相关性。 The...
The elevated activity of alkaline phosphatase in serum in hepatobiliary disease has been of established diagnostic value for nearly 60 years. The contrast between the marked elevations typically associated with obstructive jaundice and the slight to mode
For more information on the incidence and natural history of Paget’s disease of the bone in England and Wales, please click here. The Randox tests can also be carried out to determine the root cause of elevated alkaline phosphatase in the blood as well as to monitor liver damage as the ...
the elevation is likely due to liver phosphatase. These conclusions are drawn from the observation that the 4 major fractions exhibit varying heat stabilities, with placental ALP being the most heat-resistant, followed by intestinal, liver, and bone fractions in decreasing order of heat stability. ...