In conclusion, the current preclinical work demonstrates that localized pulmonary delivery of an ALK5 inhibitor leads to favorable TGF尾 pathway pharmacodynamic inhibition in lung while minimizing key systemic toxicities.doi:10.1016/j.taap.2022.115905Jonathan M.Maher...
RT‒qPCR (i) and western blots with quantitative analysis (j) of the treatment effect of the miR-1208 inhibitor were obtained from human chondrocytes (n = 3). GAPDH or U6 was used as the internal reference. Two-tailed Student’s t test or one-way analyses of variance were used ...