Description. An alkaline phosphatase (ALP) blood test assesses the level of the enzyme alkaline phosphatase in a blood sample. Alkaline phosphatase is an enzyme
As shown in Fig. 2c, exposure of cells to TAE684 markedly inhibited the phos- phorylation of ALK and downstream proteins STAT3 and ERK1/2, in a concentration-dependent manner. This effect was reduced in the resistant cell lines in compari- son with wild-type Karpas299. Although Karpas...
and multiple ALK-tyrosine kinase inhibitors (TKIs) have been sequentially used. Multiple ALK-TKI resistance mutations have been identified from the patients, and several compound mutations, such as I1171N + F1174I or I1171N + L1198H are resistant to all the approved ALK-TKIs. In t...
, 6. in part because CNS drug exposure is limited by the endothelial tight junctions and elevated expression levels of efflux transporters at the blood–brain barrier (BBB), making it difficult to reach therapeutically relevant drug concentrations at lesion sites.8 A number of brain-penetrant ...
· Hun‑Taek Kim1 Received: 4 April 2024 / Accepted: 8 July 2024 / Published online: 6 August 2024 © The Author(s) 2024 Abstract Transforming growth factor β (TGFβ) is present in blood of patients who do not respond to anti-programmed cell death (ligand) 1 [PD-(L)1] ...