ALP produced in the intestine can also increase after fatty meals in people with certain blood types. Abnormally low ALP levels are less common but can occur as a result ofmalnutrition, nutrient deficiencies, hypothyroidism, and some rare inherited disorders that affect ALP or liver function. What...
, 6. in part because CNS drug exposure is limited by the endothelial tight junctions and elevated expression levels of efflux transporters at the blood–brain barrier (BBB), making it difficult to reach therapeutically relevant drug concentrations at lesion sites.8 A number of brain-penetrant ...
. To overcome the KRAS G12C-mediated resistant, we evaluated the combination therapy of gilteritinib and KRAS G12C-specific inhibitor, AMG510 in vitro and in vivo. As a result, combined treatment with gilteritinib and AMG510 inhibited downstream pathways and showed low IC50(Supplementary Fig...