ALP produced in the intestine can also increase after fatty meals in people with certain blood types. Abnormally low ALP levels are less common but can occur as a result ofmalnutrition, nutrient deficiencies, hypothyroidism, and some rare inherited disorders that affect ALP or liver function. What...
, 6. in part because CNS drug exposure is limited by the endothelial tight junctions and elevated expression levels of efflux transporters at the blood–brain barrier (BBB), making it difficult to reach therapeutically relevant drug concentrations at lesion sites.8 A number of brain-penetrant ...
It has also been shown to penetrate blood–brain barrier. TSR-011 is a dual ALK/TRK inhibitor developed by Tesaro, Inc., Waltham, MA, USA. It is currently recruit- ing in a phase I/IIa trial (NCT02048488) [99]; Prelimin- ary results showed a dose range of 30–480 mg, with the...