ALK基因的发现史和正常生理作用,算是相当基础和经典的知识,本文就直接从ALK基因异常的促癌机制说起,在NSCLC及间变性淋巴瘤(ALCL)等ALK基因变异检出率较高的癌症中,ALK融合均为主要的致癌基因变异,而且NSCLC中检出的大多为EML4-ALK融...
ALK基因的发现史和正常生理作用,算是相当基础和经典的知识,本文就直接从ALK基因异常的促癌机制说起,在NSCLC及间变性淋巴瘤(ALCL)等ALK基因变异检出率较高的癌症中,ALK融合均为主要的致癌基因变异,而且NSCLC中检出的大多为EML4-ALK融合(约85%),具体可分为4种变体,多为V1和V3变体。 ALK基因融合发生后,会介导不...
ALK基因的发现史和正常生理作用,算是相当基础和经典的知识,本文就直接从ALK基因异常的促癌机制说起,在NSCLC及间变性淋巴瘤(ALCL)等ALK基因变异检出率较高的癌症中,ALK融合均为主要的致癌基因变异,而且NSCLC中检出的大多为EML4-ALK融合(约85%),具体可分为4种变体,多为V1和V3变体。 ALK基因融合发生后,会介导不...
江丰收教授:ALK最早于1994年在间变性大细胞淋巴瘤(ALCL)中被发现,随后包括非小细胞肺癌(NSCLC)在内的多个癌种均报告了不同类型的ALK基因重排,证实ALK是强力致癌驱动基因,为开发针对性的治疗提供了潜力靶点。 第一代ALK TKI克唑替尼在PROFILE研究中实现...
ALK基因的发现史和正常生理作用,算是相当基础和经典的知识,本文就直接从ALK基因异常的促癌机制说起,在NSCLC及间变性淋巴瘤(ALCL)等ALK基因变异检出率较高的癌症中,ALK融合均为主要的致癌基因变异,而且NSCLC中检出的大多为EML4-ALK融合(约85%),具体可分为4种变体,多为V1和V3变体。
Human cell lineTyrosine kinase receptorTK-ALCL1, a novel anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphoma (ALK+ALCL) cell line, was established from the primary tumor site of a 59-year-old Japanese male patient. The immune profile of TK-ALCL1 corresponds to that seen ...
(2p23)4,5. AberrantALKwas originally found in an ALCL cell line6,7. It was described as a product of t(2;5)(p23;q35) chromosomal translocation involving a nucleophosmin partner (NPM1)---(NPM1-ALK)7,8, discerned in 75–90% ofALK-altered ALCL cases, though otherALKfusion partners ...
CH5424802—more potent and selective ALK inhibitor—comprises a good candidate for second-line treatment in crizotinib-relapsed patients. The aim of this study was to determine possible mechanisms of resistance to ALK inhibitors that can appear in ALCL patients. Methods ALK+ ALCL cell lines ...
ALK基因变异(包括融合突变、点突变和基因扩增)导致激酶域异常激活,出现病理性ALK信号,诱发体细胞增殖和凋亡抑制,常出现在间变性大细胞淋巴瘤(anaplastic large cell lymphoma,ALCL)、炎症性肌成纤维细胞瘤(inflammatory myofibroblastic tumor,IMT)及NSCLC等恶性肿瘤[7-9]。在NSCLC中,ALK融合突变是最常见的变异类型,以...
In a first set of experiments, we used a human NPM1-ALK+ ALCL cell line (SU-DHL-1 TTA) expressing a doxycycline-inducible shRNA against ALK [39]. After doxycycline addition, SU-DHL-1 TTA cells downregulated ALK, halted proliferation and finally died (Fig. 2A–D). In parallel, they ...