Messenger RNA (mRNA) vaccines are being used to combat the spread of COVID-19 (refs. 1 , 2 , 3 ), but they still exhibit critical limitations caused by mRNA instability and degradation, which are major obstacles for the storage, distribution and efficacy of the vaccine products 4 . ...
近日,国际顶级学术期刊《Nature》正刊发表了百度与合作单位在生物计算领域的研究成果——《Algorithm for Optimized mRNA Design Improves Stability and Immunogenicity》,提出mRNA序列优化算法LinearDesign。 这是中国科技企业首次以第一完成单位的身份在《Nature》杂志发表论文。鉴于论文对生物医学领域的重要性,Nature杂志在...
the study “Algorithm for Optimized mRNA Design Improves Stability and Immunogenicity” appeared in the scientific journal Nature on May 2 through Accelerated Article Preview (AAP). This marks the first time a Chinese tech company has been credited as the first affiliation...
3h). For example, 62% of estimates lie within 3 h of the true cell phase based on the clock alone; this improves to 72% when incorporating de novo cyclers. However, unlike the results on the data simulated with pure 24 h component sinusoidal waveforms, results on these data suggest...
threshold segmentation of MRI brain images. According to Otsu and differential search algorithms, Shao et al. [9] introduced a novel ultrasound image segmentation method for multi-stage threshold segmentation. Khorram et al. [10] designed an optimized threshold method adopting texture features as ...
Through a collaboration with Oregon State University, StemiRNA Therapeutics, and the University of Rochester Medical Center, the study "Algorithm for Optimized mRNA Design Improves Stability and Immunogenicity" appeared in the journalNature. The paper reveals how a complex biology problem can be tackled...