alessio ciulli university of dundee, uk title: new insights and twists on protac and molecular glue degraders design and mechanism alessio ciulli studied chemistry in florence, italy, and obtained his phd as a gates scholar from the university of cambridge, uk, in 2006. after postdoctoral ...
日前,英国邓迪大学(University of Dundee)科学家领衔的研究团队在预印本网站ChemRxiv上发表了他们的最新研究,描述了一种三价蛋白降解嵌合体(PROTAC)分子。与常见的PROTAC分子不同,这款三价分子能够同时与两种不同的E3泛素连接酶结合,从而在增强靶点蛋白降解的同时,有望克服细胞通过丢失特定E3泛素连接酶表达产生的PROTA...