1998 Human CYP11B2 (aldosterone synthase) maps to chromosome 8q24.3. J Clin Endo- crinol Metab. 83:1033-1036.Taymans SE, Pack S, Pak E, Torpy DJ, Zhuang Z, Stratakis CA. Human CYP11B2 (aldosterone synthase) maps to chromosome 8q24.3. J Clin Endocrinol Metab. 1998;83:1033-1036....
6.5Aldosterone synthase (CYP11B2) Aldosteroneinduces the differentiation of 3T3-L1 cells into lipid-storing adipocytes[228]. The impact of the renin–angiotensin–aldosterone system onadipose tissueis considerable. Its hyperactivity inhibitspreadipocytedifferentiation and contributes to the formation of large...
87.3.2Aldosterone Synthase Deficiency Aldosteronesynthase (CYP11B2) not only has 11β-hydroxylase activity but also convertscorticosteroneto 18-hydroxycorticosterone by 18-hydroxylase and subsequent 18-oxidation of 18-hydroxycorticosterone toaldosteroneby 18-oxidase (seeFigure 87-1). Defects inaldosterone...
ChemicalBook provide Chemical industry users with Aldosterone Synthase CYP11B2 Antibody Boiling point Melting point,Aldosterone Synthase CYP11B2 Antibody Density MSDS Formula Use,If You also need to Aldosterone Synthase CYP11B2 Antibody Other information
eclampsia.In pregnant women (normotensive n = 44; pre-eclamptic n = 48), blood pressure, urinary tetrahydro-aldosterone excretion and activating polymorphisms (SF-1 site and intron 2) of the aldosterone synthase gene (CYP11B2) were determined; 185 non-pregnant normotensive individuals served as...
CYP11B2 / Aldosterone Synthase Antibody LS-C664922 中文名: 中文别名: CBNumber: CB36888922 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商1 CYP11B2 / Aldosterone Synthase Antibody LS-C664922化学性质 安全信息 CYP11B2 / Aldosterone Synthase Antibody LS-C664922性质、用途与生产工艺...
Aldosterone-producing adenomas (APAs) continue to express high levels of aldosterone synthase (CYP11B2), which maintains the capacity for aldosterone production (10–14). The expression of CYP11B2 appears to be a novel marker for APAs (15). The adrenocorticotropic hormone receptor (ACTH-R, MC2...
It has been suggested that an aldosterone synthase gene polymorphism (CYP11B2 344T/C) is predictive of the blood pressure lowering effect of angiotensin II receptor blockers in essential hypertension. We investigated whether this polymorphism is predictive of reductions in blood pressure and ...
The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds,
Aldosterone synthase (CYP11B2) inhibition has emerged as a new option for the treatment of hypertension, heart failure and renal disorders, in addition to mineralocorticoid receptor (MR) blockade. The aim is to decrease aldosterone concentrations in both plasma and tissues, thereby decreasing MR-depe...