For the Kaplan-Meier curves, p values were assessed by the log-rank test. p-value < 0.05 was considered significant. 3. Results 3.1. ALDOA knockout markedly inhibits HCC proliferation both in vitro and in vivo To explore the biological function of ALDOA in HCC, we detected the protein ...
Whereas the diagnosis of HFI can be suspected on clinical grounds, laboratory confirmation is essential. Untreated patients ingesting fructose in their diet may excrete large amounts of this sugar in their urine and also show a gross generalizedaminoaciduria. A fructose tolerance test, administered wi...
Enzymatic activities of rabbit aldolase are shown in b as the mean ± s.e.m.; n = 4 biological replicates for each concentration of aldometanib (see structure in a), and P values were determined by one-way analysis of variance (ANOVA), followed by Tukey's test. c, Aldometa...
To test the 17-HOPC-CoA–binding model, key amino acid residues in Ltp2 were altered using site-specific mutagenesis, and steady-state kinetics parameters were determined with the substrate 17-HOPC-CoA (Table 1). All Ltp2 variants can be purified as complexes with ChsH2DUF35 indicating proper...
Whereas the diagnosis of HFI can be suspected on clinical grounds, laboratory confirmation is essential. Untreated patients ingesting fructose in their diet may excrete large amounts of this sugar in their urine and also show a gross generalizedaminoaciduria. A fructose tolerance test, administered ...