This mutation leads to ALDH2 enzyme deficiency and protection against alcoholism. As yet, no polymorphism for the promoter region of the ALDH2 gene has been reported.Shoji HaradaInstitute of Community Medicine (S.H.Takehito OkuboInstitute of Community Medicine (S.H....
The study said that over 540 million people in Asia carry a mutation in the ALDH2 gene, which means they can't process acetaldehyde which causes the widely documented red flush reaction in Asians. Drinking Alcohol Causes Irreversible DNA Damage Zhou et al., "A Novel Polymorphism rs1329149 of...
Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung. Respir Res. 2017;18:69. PubMed PubMed Central Google Scholar Oka Y, Hamada M, Nakazawa Y, Muramatsu H, Okuno Y, Higasa K, et al. Digenic mutations in ALDH2 and ADH5 impair ...
Integrated amplification and detection of the C677T point mutation in the methylenetetrahydrofolate reductase gene by fluorescence resonance energy transfer and probe melting curves[J]. Anal Biochem, 1998,255(1):101-107. [11] 李志祥,谢桂岚. ALDH2基因第12外显子(G/A) 多态性在北京汉族人群的检测...
Human ALDH2 gene is mapped to chromosome 12q24. A sequence rs671 polymorphism (also named Glu487Lys, or Glu504Lys) has been widely studied. There is a G-to-L missense mutation in which glutamate at position 504 is replaced by lysine, then forms GG, GL and LL three patterns (also ...
The prevalence of G to A mutations is consistent with previous reports of gene mutation pattern in ESCC [18,58]. We summarize the data regarding our experimental model of alcohol-induced field cancerizations as follows. Chronic alcohol exposure in KTPA–/– (TP53–/–; Aldh2–/–) mice ...
As an oxidative stress-based model of age-dependent cognitive impairment and neurodegeneration, theAldh2-/-mice have distinct advantages over mice expressing the Glu504Lys mutation of ALDH2 (ALDH2*2) [33]. UnlikeAldh2-/-mice, no pathological or cognitive changes were seen in 6 month old ALDH...
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The contribution of any single gene in a multifactorial dis- ease such as stroke is modest. Proteomics, the study of the entire protein content of a cell or tissue, may be a prom- ising approach to identify new biomarkers for stroke [17]. In this study, we used fluorescent two-...
本发明涉及体外核酸检测技术领域,尤其涉及一种焦磷酸测序法检测乙醛脱氢酶2(ALDH2)基因分型的引物对及试剂盒。 背景技术 人类乙醛脱氢酶(Aldehydedehydrogenasegene,ALDH)是一种四联体蛋白,催化乙醛和其他脂肪族醛氧化。目前,已发现ALDH有19种同工酶,主要有ALDH1~4四种,其中ALDH2最为重要。在肝和胃中具有很高的表达...