To delve into the intricate molecular pathways underlying the therapeutic effects of WEL and DWEL on NAFLD, RNA sequencing was conducted on the zebrafish liver from the control, NAFLD, as well as WEL and DWEL treatment groups. Utilizing the transgenic zebrafish with liver-specific fluorescent protein...
The performance of MRE is better than that of VCTE-LSM in diagnosing advanced fibrosis in NAFLD patients [66]. However, unlike VCTE, it is difficult to implement MRE at a large scale since it requires an MRI facility, is associated with a high cost, and is time-consuming. Evolving non-...
The liver biopsy, albeit imperfect, remains the gold standard for the diagnosis, assessment of disease activity and response to treatment in NAFLD. In an early landmark study, Skellyet al.19highlighted the importance of liver biopsy in the context of NAFLD; in their cohort of 354 patients who...
All animals were received in a single shipment, quarantined for 2 weeks, then housed in a standard animal facility with ad libitum access to standard chow and drinking water. Prior to experimentation, the animals were randomized into 4 groups: Intact (0.9% NaCl; n = 10), Control (NAFLD ...