Our findings also showed that treatment with IL-6 ameliorates fatty liver disease in alcohol-fed mice, high-fatdiet fed mice, and genetically modified ob/ob mice. It is believed that the action of IL-6 is mediated via activation of signal transducer and activator of transcription 3 (STAT3)....
Evaluation of blood oxidative stress-related parameters in alcoholic liver disease and non-alcoholic fatty liver disease. Scand J Clin Lab Invest. 2008;68:323–34.Das KS, Balakrishnan V, Mukherjee S, Vasudevan DM. Evaluation of blood oxidative stress-related parameters in alcoholic liver disease ...
Alcoholic liver disease (ALD), including alcoholic hepatitis, is the most prevalent liver disease worldwide. ALD is defined by the accretion of neutral lipids and lipid metabolism disruption prior to liver damage. Obesity is another risk factor for ALD development; the incidence of ALD increases by...
Our findings demonstrate that CD36 expressed on hepatocytes and hepatic macrophages mediates the pathophysiology of NASH. Laboratory Investigation (2012) 92, 265–281; doi:10.1038/labinvest.2011.159; published online 7 November 2011 KEYWORDS: CD36; high-fat diet; inflammation; mice; NASH; oxidized ...
In addition, our dose–response results were consistent with the findings of a phase 2 trial of semaglutide among patients with NASH [40], showing dose-dependent reductions in liver-related biomarkers (i.e., ALT, AST, and cytokeratin-18 fragments). Hence, GLP-1RAs may also be recommended ...
Nonalcoholic fatty liver (NAFL) and its sequelae are growing health problems. We performed a genome-wide association study of NAFL, cirrhosis and hepatocellular carcinoma, and integrated the findings with expression and proteomic data. For NAFL, we utilized 9,491 clinical cases and proton density ...
Specifically, the role of liver biopsy in ALD is 1) to corroborate clinical findings in establishing diagnosis and 2) to estimate disease severity using semi-quantitative tools of disease grade and stage. The objective of this review is to survey the gross and microscopic features of ALD and, ...
Findings in the literature indicate that pyrazole alone does not cause liver damage when given to mice [32]. Hepatocellular damage requires pyrazole to act in combination with alcohol. Therefore, the induction of alcoholic liver disease in mice requires the administration of both alcohol and pyrazole...
Additionally, the activation of GR in hepatic stellate cells inhibits liver fibrosis [59], whereas HSD11β1 deficiency or inhibition enhances myofibroblast activation and promotes liver fibrosis [60]. All these clinical and experimental findings support a key liver-protective role of hepatic GR in ...
re at risk for MASH or if other tests show that you may have MASH complications such as cirrhosis. It is considered the gold standard for diagnosing and assessing liver fibrosis. A doctor removes a sample of tissue from your liver and sends it to a lab to see if you have liver...