The exact mechanism underlying this toxicity is still unclear, although one hypothesis is that methotrexate causes mitochondrial dysfunction16,17. However, methotrexate is a substrate for a wide range of drug transporters (Table 1) and their expression and/or function is altered in NAFLD170. Another...
Here, we have demonstrated that hepatic WTAP integratively regulates lipoatrophy, ectopic lipid accumulation and inflammation during NASH progression. Hepatic deletion ofWtapinduces the expression and secretion of IGFBP1, which enhances lipolysis in the eWAT and increases serum FFAs, leading to hepatic s...
The mechanism of L-theanine on AALI may be the same in mice and LO2 cells. Abstract Acute alcoholic liver injury (AALI) refers to the inflammatory hepatic damage caused by alcohol. In severe cases, it can lead to steatohepatitis, alcoholic fibrosis and even cirrhosis. In this study, we an...
15. However, the underlying mechanism of the beneficial effects of exercise and diet on NAFLD, as well as the related metabolic disorders through regulation of the gut microbiota, still remain to be elucidated.
Consequently, GAS5/miR-28a-5p/ MARCH7/NLRP3 signalling-mediated pyroptosis might be the underlying mechanism of NAFLD pathogenesis. GAS5, miR-28a- 5p, MARCH7, NLRP3, and pyroptosis might be potential biomar- kers for NAFLD diagnosis and treatment. Cell Death & Differentiation (2023) 30:1829...
(CXCL)1;CXCL2;andTNF-伪;inmonocyteswasevaluated.RESULTSRIP3KOHFdietfedmiceshowedasignificantgaininbodyweight;andliverweight;livertobodyweightratio;andlivertriglycerideswereincreasedinHFdietfedRIP3KOmicecomparedtoHFdietfedWTmice.RIP3KOprimaryhepatocytesalsohadincreasedintracellularfatdropletscomparedtoWTprimary...
Interestingly, although DRAK2 was discovered as a positive regulator of apoptosis (Sanjo et al., 1998), the mechanism by which DRAK2 functions in apoptosis remains unclear. We found that Drak2-HKO improves HFF-diet-induced liver injury and inflammation, and the PA/TNFα-induced hepatocyte ...
Regulatory mechanism of AMP-dependent protein kinase (AMPK) by alcohol and other non-alcoholic substances, including high fat diet has become an important research topic, since AMPK serves as a key sensor and/regulator of metabolic syndrome and many cellular processes [136]. In fact, the redox ...
Thus, the decrease in hepatic GR proteins is an important mechanism of acquired GCR; however, other mechanisms of GCR also exist. sAH patients are highly susceptible to sepsis, and sepsis is a leading cause of death in sAH [131,132]. A recent study indicates that decreases in the DNA ...
Alcohol is then metabolized by the alcohol dehydrogenase (ADH)-mediated system; microsomal ethanol oxidizing system, which is a non-ADH system; and nicotinamide-adenine dinucleotide phosphate oxidase–catalase reaction system, which is a non-ADH system [34]. Prolonged excessive drinking induces the ...