Low levels of Zn in the brain during alcohol intoxication may increase sensitivity to alcohol withdrawal-induced seizures, and Zn supplementation may prevent alcohol withdrawal symptoms [139]. Zinc has been shown to improve the intestinal mucosal barrier in animal models of ALD and small pilot ...
This allows for a clinically unrecognizable transition from alcoholic hepatitis with fibrosis to irreversible cirrhosis. However, AC can also develop without ASH or AH. In rare cases, a fifth hit initiates the development of a hepatocellular carcinoma (HCC), mostly occurring in patients with ...