Alcohol-related cirrhosisPNPLA3HSD17B13TM6SF2risk predictionHepatocellular carcinoma (HCC) is the most common primary liver malignancy, with increasing incidence worldwide. Alcohol-related cirrhosis (AC) accounts for 30% of the global incidence of HCC and HCC-related deaths. With the decline of hep...
Alcohol use is the main risk factor for ARLD, and alcohol consumption is positively correlated with the risk of ARLD7,8. However, only about 1-in-3 heavy drinkers develop alcohol-related cirrhosis (the end stage of ARLD), and case-control and cohort studies demonstrate considerable heterogenei...
Genome-wide association study for alcohol-related cirrhosis identifies new risk loci in MARC1 and HNRNPUL1doi:10.1016/S0168-8278(20)30754-6Hamish InnesStephan BuchSharon HutchinsonNeil GuhaJoanne MorlingEleanor BarnesWilliam IrvingEwan ForrestVincent Pedergnana...
The measure of life-time alcohol consumption in patients with cirrhosis: reproducibility and clinical relevance Our aims were to design a reproducible method of measuring life-time alcohol consumption in patients with cirrhosis, and to assess the risk of liver decomp... S Arico,G Galatola,M Tab...
Over time, too much scarring in the liver can lead to cirrhosis. It’s a life-threatening, late-stage liver disease that can stop the liver from properly filtering blood. This can cause other organs in your body to shut down and increase your risk for death. Cirrhosis usually takes decade...
Alcohol-related cirrhosis—early abstinence is a key factor in prognosis, even in the most severe cases. Addiction. 2009;104(5):768-774.PubMedGoogle ScholarCrossref 25. Moriarty K, Cassidy P, Dalton D, et al. Alcohol-Related Disease. Meeting the challenge of improved quality of care and...
An international research group led by the Centenary Institute has developed a world first genetic risk score (GRS) test able to identify patients at high-risk of developing alcohol-related cirrhosis. Cirrhosis (scarring of the liver) is responsible for approximately 300,000 deaths each year world...
The risks in women of cirrhosis with a likely primary alcohol aetiology were estimated for various levels of alcohol consumption in a case-control study. Data were obtained from 41 women with a first diagnosis of cirrhosis who had no evidence of non-alcohol-related cirrhosis; three matched contro...
and confirmed rs738409 inPNPLA3as an important risk locus for alcohol-related cirrhosis (P= 1.54 × 10−48) at a genome-wide level of significance. These three loci have a role in lipid processing, suggesting that lipid turnover is important in the pathogenesis of alcohol-related cirrhosis...
TREATMENT of cirrhosis of the liverSTATINS (Cardiovascular agents)ALCOHOLISMLIVER cancerMORTALITYANTICHOLESTEREMIC agentsThis is linked to Bang et al papers. To view these articles visit https://doi.org/10.1111/apt.14243 and https://doi.org/10.1111/apt.14281.doi:info:doi/10.1111/apt.14277...