Data collected at screening, baseline and throughout the study included: demographics, measures of alcohol use, subjective response to psilocybin and diphenhydramine, and safety measures. The primary outcome was the proportion of heavy drinking days during the 32 weeks after the first dosing session ...
Alcohol use disorder (AUD) is a widespread disease leading to the deterioration of cognitive and other functions. Mechanisms by which alcohol affects the brain are not fully elucidated. Splicing constitutes a nuclear process of RNA maturation, which results in the formation of the transcriptome. We...
Increased decision latency in alcohol use disorder (AUD) has been generally explained in terms of psychomotor slowing. Recent results suggest that AUD patients’ slowed decision-making might rather reflect alterations in the neural circuitry underlying the engagement of controlled processing by salient sti...
use disorder diagnoses (Miele et al., 2000); (c) DSM-IV Diagnostic Interview, a semistructured, clinician-directed interview (utilized in CTN 013) used to determine DSM substance use diagnoses; and (d) Composite International Diagnostic Interview 2.1 Substance Use Module (CIDI 2.1, SUD module)...
This national epidemiologic survey finds that alcohol use disorder is highly prevalent, highly comorbid, and disabling, with an urgent need for education
Exclusion criteria were (1) marked functional impairment from bipolar disorder or schizophrenia38,39; (2) current abstinence from alcohol and/or opioids in the previous 30 days; and (3) current substance use treatment. Participants gave written informed consent and were compensated for research ...
Existing epidemiological evidence for alcohol use disorder (AUD) supports the notion that women who have ever had children (mothers) experience a motherhood advantage; that is, they exhibit lower rates of AUD than women who have never had children (nonmothers) [1–3]. A lifetime motherhood rol...
Mental health needs were assessed using the Strengths and Difficulties Questionnaire, the Conners screen for Attention Deficit Hyperactivity Disorder and a brief measure ascertaining demographics, drug use, and the service required by young people. Results. Young people were found to have higher than ...
GDAP1; alcohol use disorder; H3K4me3; DNA-methylation; epigenetics; gene expression1. Introduction Alcohol is an addictive and psychoactive substance with major health implications. It has been ranked as the third most relevant health risk factor next to high blood pressure and smoking according to ...
People with alcohol use disorder (AUD) who are at risk of advanced liver disease are less likely to be referred for liver evaluation and care if they present primarily with alcohol-related mental health issues or a mental health diagnosis, according to a study of referral practices in Virginia...