Most alcohol dehydrations take place by the mechanism shown below. Protonation of the hydroxyl group allows it to leave as a water molecule. The species that remains has a carbon atom with only three bonds and a positive charge and is called a carbocation. This intermediate species can be sta...
Nestel PJHirsch EZ Mechanism of alcohol-induced hypertriglyceridemia. J Lab Clin Med 1965;66 (3) 357- 365PubMedGoogle Scholar 69. Sun GYRush AChin PCGorka CLahiri SWood WG Serum lipids and acyl group composition of alcoholic patients. Alcohol 1988;5 (2) 153- 157PubMedGoogle ScholarCross...
Concealment mechanism {16b} The allocation table was prepared by an independent statistician not involved in the study. The randomisation is conducted in REDCap using this pre-specified allocation table, which prevents study staff from anticipating the allocation sequence. Implementation of the randomisati...
indices of anxiety. In startle paradigms, the startle response is a defensive mechanism reflecting anxiety which follows a sudden, unpredictable stimulus (e.g., tones, light) [101]. In light-dark box paradigms, anxiety is elicited using a testing apparatus with a light and dark compartment, re...
Interestingly, a Su(H) binding site is predicted near the intronic branchpoint between Dop2R’s exons 7 and 8, which suggests a possible mechanism by which Notch activity could influence the splicing machinery and result in the expression of alternative transcript isoforms. Although the functional...
of genetic factors influencing AC with genetic risk variants for AUD. Our Mendelian randomization finding suggests that the underlying biological mechanism for heavy AC might also be relevant in the pathophysiology of AUD. Based on these results we further analyzed if AC MRSs can predict AUD risk....
To understand the mechanism behind resistance exercise to improve strength in PAE rats, we measure the levels of the myokine Irisin in plasma after resistance exercise for 4 weeks. When comparing group control and PAE after exercise and did not find significant differences (11.5 ± 1.8 ng/...
Levels of aldehyde dehydrogenase 2 (ALD2), involved in an anti-hangover mechanism, were measured by semi-quantitative RT–PCR and western blot analysis. Results: Rosiglitazone caused an upregulation of mitochondrial ALD2, thus significantly detoxifying acetaldehyde. Conclusions: Rosiglitazone alleviated ...
Although the processes by which activation of mGluR5 receptors enhance cognition are not clear, one potential mechanism may be through indirect actions on NMDA receptors. Blockade of the NMDA receptor has been shown to significantly impair performance in an operant set- shifting task likely through ...
Mechanism of action In pharmaceutical applications, benzyl alcohol acts as a solvent, allowing the dissolution of hydrophobic drugs. It can also function as a preservative by inhibiting the growth of bacteria and fungi. In the personal care industry, benzyl alcohol provides a pleasant scent to produ...