1999. Association of alcohol in brain injury, headaches, and stroke with brain-tissue and serum levels of ionized magnesium: a review of recent findings and mechanism of action. Alcohol 19: 119-130.ALTURE BM,ALTURA BT. Association of alcohol in brain injury,headaches,and stroke with brain-...
Baclofen, a medication that has long been used to treat increased muscular tension in certain neurological states, has also been studied for the treatment of alcohol dependence. Results have been promising, but the mechanism has been unclear. "One of the things baclofen does is to suppress GABA ...
Frontiers of alcoholism Frontiers of alcoholism ed. by Morris E. Chafetz, Howard T. Blane, Marjorie J. Hill Science House, 1970 ME Chafetz,HT Blane,MJ Hill - Science House 被引量: 32发表: 1970年 Ethanol-derived acetaldehyde: pleasure and pain of alcohol mechanism of action Frontiers in ...
Preclinical studies have provided the opportunity to dissect these interactions in some detail and although we do not fully comprehend the actions of ethanol there have been some great advances resulting in increased knowledge of the complexity of ethanol's mechanism of action in this system. 展开 ...
Its mechanism of action is not completely understood; gabapentin seems to exert its effect by selectively inhibiting voltage-gated Ca2 + -channels and increasing GABA neurotransmission, as well as modulating the excitatory amino acids at N-methyl-D-aspartic acid (NMDA) receptor sites (McLean, 1999...
3. Blum K et al., “Hypothesizing Darkness Induced Alcohol Intake Linked to Dopaminergic Regulation of Brain Function.” HHS Public Access Author Manuscript 2014 Jul 7 PMID25009759[cited 2022 Aug 25] 4. Singh U, “Mechanism of Alcohol Induced Neurotoxicity.” NIH publication (Abstract) [online...
Alcohol use disorder (AUD) is a widespread disease leading to the deterioration of cognitive and other functions. Mechanisms by which alcohol affects the brain are not fully elucidated. Splicing constitutes a nuclear process of RNA maturation, which resu
To understand the neuronal context of Sca, we examined protein localization in the adult brain. In developing tissue, Sca is secreted and diffuses up to three cell diameters away from its origin, which makes it challenging to determine its source and site of action (Lee et al., 1996). Dif...
indices of anxiety. In startle paradigms, the startle response is a defensive mechanism reflecting anxiety which follows a sudden, unpredictable stimulus (e.g., tones, light) [101]. In light-dark box paradigms, anxiety is elicited using a testing apparatus with a light and dark compartment, ...
(RapaBlock) to protect mTORC1 activity in the periphery. We show that whereas RapaLink-1 administration blocked mTORC1 activation in the liver, RapaBlock abolished the inhibitory action of Rapalink-1. RapaBlock also prevented the adverse side effects produced by chronic inhibition of mTORC1. ...