A chemical that kills germs, such as bacteria, to prevent contamination and infection. DrugBank ID DB02325 Type Small Molecule US Approved YES Other Approved YES Patents 21 Indicated Conditions 1 Clinical Trials Phase 0 1 Phase 1 6 Phase 2 14 Phase 3 35 Phase 4 23 Mechanism of Action Nitric...
How do bacteria accomplish chemotaxis? How are bacterial cells resistant to ampicillin? Rubbing alcohol explain (1) the mechanism by which it kills microorganisms or inhibits their growth and (2) the means through which microorganisms may become resistant to it's effects. How do bacteria become re...
The mechanism of ethanol's action on the immune system however, are not fully understood. Cyclic AMP (cAMP) is known for its immunosuppressive effects and also is required for proper development of the immune system. Previous work in our laboratory has demonstrated that ethanol enhances the ...
Accumulating evidence in the past several years has established associations between the gut microbiome and microbial metabolites with drinking behavior, but druggable targets and their underlying mechanism of action are understudied. Results Here, using a drink-in-the-dark mouse model, we identified a...
Mechanism of action In pharmaceutical applications, benzyl alcohol acts as a solvent, allowing the dissolution of hydrophobic drugs. It can also function as a preservative by inhibiting the growth of bacteria and fungi. In the personal care industry, benzyl alcohol provides a pleasant scent to produ...
The exact mechanism of action in cancer has not been elucidated, however it is probably related to TGF-β and the Ras/ERK pathway.157 POH has been used in the treatment of several malignant tumors, including gliomas. It also induces growth arrest and apoptosis of leukemia158 and breast ...
Unfortunately, contrary to fatty acid uptake research, information on the mechanism of fatty acid secretion is scarce. As a consequence, few studies have focused on the identification of transporters specifically responsible for fatty acid secretion, even in model microorganism such as E. coli and S...
Computer modeling can help. This approach is called in silico — similarly to in vivo (in a living body) and in vitro (in a test tube). It allows numerical models to be used to test hundreds of various medications and determine their potential effectiveness and the mechanism of action. Che...
and make up a separate structural family[133–136]. Although their mechanism of oxidation has been controversial[137,138], structural, mechanistic, and computational studies support a mechanism similar to that of thealcohol oxidases, hydride transfer from the alkoxide form of the substrate[139–141...
Besides, the enzymes show activity on the hydrated forms of the corresponding aldehydes. Some AAO features, such as the broad range of substrates that it can oxidize (with the only need of molecular oxygen as co-substrate) and its stereoselective mechanism, confer good properties to these ...