In addition, alcohol is known to interact with other substances of abuse, such as tobacco. Cytochrome P450 2E1 (CYP2E1), which is induced by alcohol, is mainly involved in alcohol metabolism in the liver and extra-hepatic cells in chronic users. As a result of alcohol metabolism, CYP2E1...
Alcohol is can interact with neurotransmitter in the brain. It makes the action of alcohol in the brain more complex. It affects the dopamine system by increasing the dopamine in the brain reward center. This produces the feeling of wanting to drink more alcohol to get more dopamine release. ...
Many medications can interact with alcohol, thereby altering the metabolism or effects of alcohol and/or the medication. Some of these interactions can occ... R Weathermon,DW Crabb - 《Alcohol Research & Health the Journal of the National Institute on Alcohol Abuse & Alcoholism》 被引量: 322...
33. TheMTHFRgene is known to be involved in folate metabolism, playing an essential role in inherited DNA methylation profiles, andMTHFRC677T is a common polymorphism encoding an enzyme whose activity level is affected
organism and/or interact with cognition and impact the efficacy of goal-directed behaviour. The most widely instrumentalized drug for self-management is alcohol (ethanol) [3,4,5,20,21,22]. However, human beings with a genetic risk or submitted to environmental risk conditions can develop ...
Gender influences how people view themselves and each other, how they behave and interact and how power is distributed in society. Jurisdictional claims Elsevier respects the decisions taken by its authors as to how they choose to designate territories and identify their affiliations in their ...
Nicotine and alcohol are abused substances that are often used concurrently. Despite their combined usage, little is known about how they interact to produ... RK Bachtell,AE Ryabinin - 《Neuroscience》 被引量: 52发表: 2001年 加载更多研究...
For instance, the Notch intracellular domain might interact with the highly studied CREB (Ca2+/cyclic AMP [cAMP]-responsive element-binding protein)/CBP (CREB-binding protein) pathway to influence transcriptional output (Hallaq et al., 2015, Hirano et al., 2016, Zhang et al., 2013a, Zhang ...
Alcohol-related liver disease (ARLD) represents a major public health burden. Identification of high-risk individuals would allow efficient targeting of public health interventions. Here, we show significant interactions between pattern of drinking, gene
Very little is known about patterns of tobacco and alcohol co-use in adolescence and young adulthood and how genetic and environmental influences interact to predict risk. This is particularly important because co-use has substantially greater negative health effects than tobacco or alcohol use alone....