The human microsomal epoxide hydrolase gene (EPHX1): complete nucleotide sequence and structural characterization. Consideration of multiple polymorphisms in NAT1, NAT2, SULT1A1, SULT1A2, CYP1A1 and EPHX1 enables haplotype analysis allowing for linkage disequilibrium (... C Hassett,KB Robinson,NB ...
Alcohol may occur naturally in the reproductive structures of many angiosperm plants, or it can be produced by fermenting nectar or ripe fruit [6]. As such, it is naturally available and many species have been exposed to it for a long time throughout evolution [7]. The consumption of ferme...
substantial contribution of thisenzymein local ethanol developmentalcentral nervous system toxicity. On the other hand, polymorphisms in the humanADH2gene have been associated with alcoholism.72 View chapterExplore book Alcohol use disorder pharmacotherapy options for postmenopausal females...
Zhang, "Genetic polymorphisms in cytochrome P450s, GSTs, NATs, alcohol consumption and risk of Non-Hodgkin lymphoma," American Journal of Hematology, vol. 85, no. 3, p. 213-215, 2010.Li Y, Zheng T, Kilfoy BA, et al. Genetic polymorphisms in cytochrome P450s, GSTs, NATs, alcohol ...
Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk. Methods Data from 26 case-control studies in the INHANCE Consortium were used, including never and cu...
Several animal systems have been used to model different aspects of human alcohol-related phenotypes, including preference for alcohol consumption and withdrawal (Bennett et al.2006). Rodents are suitable models for studies on genetic susceptibility for alcohol dependence, since the organization of region...
KLB encodes β-klotho, co-receptor for the liver-derived hormone fibroblast growth factor 21 (FGF21). In mice, FGF21 reduces alcohol intake, and human Fgf21 variants are enriched among heavy drinkers. Thus, the liver may limit alcohol consumption by secreting FGF21. However, whether full-...
Fatty degeneration of the liver, as a pathological change, was first proposed by William Bowman who found that fat accumulation in the liver through observing human liver specimens under the microscope in 1842.19 For the next hundred years, it was generally believed that long-term alcohol consump...
Springer for Research & Development AlcoholProsaccadeAntisaccadeIntoxicationInhibitionRationale Alcohol affects a variety of human behaviors, including visual perception and motor control. Although recent research has begun to explore mechanisms that mediate these changes, their exact nature is still not well...
(AA adducts) are formed by the interaction of acetaldehyde, a direct metabolite of ethanol oxidation and a human carcinogen, with certain amino acids, including lysine, cysteine, and aromatic amino acids. However, these amino acids in different proteins may exert an unequal preference for AA ...