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(±)-Modafinil (MOD) is used clinically for the treatment of sleep disorders and has been investigated as a potential medication for the treatment of psychostimulant addiction. However, the therapeutic efficacy of (±)-MOD for addiction is inconclusive.
The gateway hypothesis posits that initial exposure to legal drugs promotes subsequent addiction to illicit drugs. However, epidemiological studies are correlational and cannot rule out the alternative hypothesis of shared addiction vulnerability to lega
The day after the completion of training, rats received systemic injections of drugs targeting the adrenergic system 30 min before the memory reactivation session. During this session, nosepokes led to the presentation of the light CS and activation of the pump that delivered ethanol during train...
On arrival, all participants were sober (BrAC=0.0 g/kg) and had negative test results for a urine screening of illicit drugs and pregnancy in women. All study procedures, including alcohol administration, are detailed elsewhere (Marxen et al, 2014;Gan et al, 2014). For the placebo-cont...
Drugs and Chemicals MT-7716,(R)-2-{3-[1-(acenaphthen-1-yl)piperidin-4-yl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}-N-methylacetamide hydrochloride hydrate, Ro 64–6198, J-113397 (non-peptidergic NOP receptor antagonist) and diazepam were synthesized at Mitsubishi Tanabe Pharma Corporation...
The order of dosing either within drug (in the cases of dose–response studies) or across drugs (in the cases of co-infusion studies) was pseudo counterbalanced, and 2–4 days were allowed between microinfusions to re-establish baseline intake (see also Cozzoli et al, 2009; 2012). ...
Group II metabotropic glutamate receptors (mGluR2 and mGluR3) may control relapse of alcohol seeking, but previously available Group II agonists were unable to discriminate between mGluR2 and mGluR3. Here we use AZD8529, a novel positive allosteric mGluR
Upper panel: sessions using a combination of a social stress task and presentation of physical alcohol cues (Trier Social Stress/cue-reactivity test ‘Trier/CR’). Lower panel: sessions using guided imagery induced by auditory scripts. PowerPoint slide Full size image...