A complete frame-by-frame instructor's manual with notes is included. This manual keeps you on target in this presentation if you choose to give it live, but it is not necessary. All formats have professional narration. You can do a short presentation with this package or comeback and deli...
However, it is unknown if genes that encode KCa2 channels (KCNN1-3) influence alcohol and drug addiction. In the present study, an integrative functional genomics approach shows that genetic datasets for alcohol, nicotine, and illicit drugs contain the family of KCNN genes. Alcohol preference ...
Except for the alcohol studies, all animal housing and experiments were conducted in facilities with full accreditation by the Association for Assessment and Accreditation of Laboratory Animal Care. Drugs See Supplementary Information for details. Cue-Induced Reinstatement of Alcohol-Seeking Behaviour in ...
With this in mind, the primary purpose of this cluster randomized controlled trial is to provide screening for alcohol misuse and to test the efficacy of brief interventions in reducing alcohol intake in those patients with active TB found to be misusing alcohol in primary health care clinics in...
The day after the completion of training, rats received systemic injections of drugs targeting the adrenergic system 30 min before the memory reactivation session. During this session, nosepokes led to the presentation of the light CS and activation of the pump that delivered ethanol during train...
The gateway hypothesis posits that initial exposure to legal drugs promotes subsequent addiction to illicit drugs. However, epidemiological studies are correlational and cannot rule out the alternative hypothesis of shared addiction vulnerability to lega
On arrival, all participants were sober (BrAC=0.0 g/kg) and had negative test results for a urine screening of illicit drugs and pregnancy in women. All study procedures, including alcohol administration, are detailed elsewhere (Marxen et al, 2014;Gan et al, 2014). For the placebo-cont...
Drugs and Chemicals MT-7716,(R)-2-{3-[1-(acenaphthen-1-yl)piperidin-4-yl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}-N-methylacetamide hydrochloride hydrate, Ro 64–6198, J-113397 (non-peptidergic NOP receptor antagonist) and diazepam were synthesized at Mitsubishi Tanabe Pharma Corporation...
Group II metabotropic glutamate receptors (mGluR2 and mGluR3) may control relapse of alcohol seeking, but previously available Group II agonists were unable to discriminate between mGluR2 and mGluR3. Here we use AZD8529, a novel positive allosteric mGluR
Given that the discriminative stimulus effects of drugs are determinants of abuse liability and can influence drug seeking, we examined the contributions of mGlu2/3 receptors in modulating the discriminative stimulus effects of alcohol. In male Long-Evans rats trained to discriminate between alcohol (...