Acute and chronic alcohol exposure significantly affect behavior but the underlying neurobiological mechanisms are still poorly understood. Here, we used functional connectivity density (FCD) mapping to study alcohol-related changes in resting brain activity and their association with behavior. Heavy ...
Drinking alcohol excessively can also get in the way of other activities, your relationships, and your self-esteem, which can further affect your mental health. Alcohol can make you more likely to be depressed, and being depressed can make you more likely to drink alcohol. People who have...
during adolescence, may have upshots that are not necessarily the sum of those observed with ethanol or energy drinks alone and permanently affect hippocampal plasticity," write the researchers.研究
The compound significantly decreased alcohol intake in the alcohol-dependent rats and did not affect the intake of the non-dependent rats. Additional results found that the compound was particularly effective at decreasing alcohol intake among a subgroup of rats: those that ...
A baby cannot process alcohol as well as an adult, and too much exposure to alcohol in pregnancy can seriously affect development. Drinking alcohol, particularly in the first three months of pregnancy, increases the risk of miscarriage, premature birth, and the baby having a low birth weight. ...
Alcohol is a depressant. That means it can affect your brain and nervous system, slowing your breathing, your heart rate, and other important tasks that your body does. Your liver usually does a good job of keeping alcohol's toxins from getting into your bloodstream. But if you drink a lo...
Three studies investigated glutamate-related processes in the NAc [106,107,118]. Two weeks of voluntary binge drinking (4-h access, no abstinence) did not affect expression of calcium-dependent kinase II alpha (CaMKIIα) and the AMPA receptor GluA1 subunit in the NAc of mice [107]. In co...
For example, gene expression profiling on the prefrontal cortex identified 129 altered genes in patients with AUD16. Likewise, microarray analysis detected 163 differentially expressed genes in the superior frontal cortex in AUD8. However, to what extent alcohol can affect transcriptome post...
Specific genes are associated with alcohol metabolism and the effects of alcohol on the brain. For instance, variations in the genes encoding alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) affect how alcohol is processed in the body, impacting an individual’s susceptibility to ...
Rather, there are probably a large number of genes, each with rather small individual effects, that affect the risk of developing alcoholism. Recent evidence indeed suggests that much of the genetic risk is not due to neurological vulnerability but to a heightened resistance to the unpleasant ...